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Trials
Asciminib Monotherapy, With Dose Escalation, for 2nd and 1st Line Chronic Myelogenous Leukemia

trialsTrialActive

Asciminib Monotherapy, With Dose Escalation, for 2nd and 1st Line Chronic Myelogenous Leukemia

A phase 2 trial of Asciminib in chronic myeloid leukaemia, run by Novartis Pharmaceuticals, active and no longer recruiting.

Overview Connected6

Overview

Asciminib Monotherapy, With Dose Escalation, for 2nd and 1st Line Chronic Myelogenous Leukemia is a phase 2 interventional study registered as NCT05384587 by Novartis Pharmaceuticals, with 34 participants enrolled, started 2022-11-11 and due to reach its primary completion in 2025-08-13. Interventions recorded: asciminib.

Setting

A Phase II Multicenter, Open-label, Single-arm Dose Escalation Study of Asciminib Monotherapy in 2nd and 1st Line Chronic Phase - Chronic Myelogenous Leukemia (ASC2ESCALATE)

Phase

Phase 2

Sponsor

Novartis Pharmaceuticals

Registry

Started

2022-11-11

Enrolled

34 enrolled

Connected

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cancers

Chronic myeloid leukaemia (CML)Chronic myeloid leukaemia, chronic phase

technologies

Small-molecule kinase inhibitors

drugs

ApprovedSmall-molecule allosteric ABL1 inhibitor (STAMP)

Asciminib · Scemblix

companies

Advanced Accelerator Applications (Novartis)Novartis

Evidence strength28/100 · Preliminary

How much and what kind of evidence, not how big the benefit. Click for the breakdown.

Phase 2+15
34 enrolled+8
No structured primary endpoint0
Result: active0
No independent replication recorded0
A linked product is approved+5

Formula disclosed on the evidence page.

ProvenanceLast edited 2026-09-22 · Jude Gomila · Wave 2 corpus-only joins applied · diff · file

Sources & links

ClinicalTrials.gov NCT05384587

Data

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How review works

Cancers

Chronic myeloid leukaemia (CML)
Chronic myeloid leukaemia, chronic phase

Technologies

Small-molecule kinase inhibitors

Products

Asciminib

Companies

Novartis

Not yet reviewedNeeds expert (clinical) review. Review this page or see the review queue and roster.

Model panel commentary is coming to this page: machine commentary, not clinical review.

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