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Trials
A Study of BGB-11417 in Participants With Myeloid Malignancies

trialsTrialRecruiting

A Study of BGB-11417 in Participants With Myeloid Malignancies

A phase 1/2 trial of Sonrotoclax and Azacitidine in acute myeloid leukaemia and myelodysplastic syndromes / neoplasms, run by BeOne Medicines, now recruiting.

Overview Connected7

Overview

A Study of BGB-11417 in Participants With Myeloid Malignancies is a phase 1/2 interventional study registered as NCT04771130 by BeOne Medicines, with 260 participants planned, started 2021-05-24 and due to reach its primary completion in 2028-08-31. Interventions recorded: BGB-11417, Azacitidine and Posaconazole.

Setting

A Phase 1b/2, Open-Label, Dose Finding, and Expansion Study of the Bcl-2 Inhibitor BGB-11417 in Patients With Myeloid Malignancies

Phase

Phase 1/2

Sponsor

BeOne Medicines

Registry

Started

2021-05-24

Enrolled

260 enrolled

Connected

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cancers

Acute myeloid leukaemia Myelodysplastic syndromes / neoplasms (MDS)

technologies

BCL-2 inhibitors Small-molecule kinase inhibitors

drugs

ApprovedSmall-molecule hypomethylating agent (cytotoxic)

Azacitidine · Vidaza / Onureg (oral)

ApprovedSmall-molecule BCL-2 inhibitor (second generation)

Sonrotoclax · Beqalzi

companies

BeOne Medicines (formerly BeiGene)

Evidence strength25/100 · Preliminary

How much and what kind of evidence, not how big the benefit. Click for the breakdown.

Phase 1/2+8
260 enrolled+12
No structured primary endpoint0
Result: recruiting0
No independent replication recorded0
A linked product is approved+5

Formula disclosed on the evidence page.

ProvenanceLast edited 2026-09-22 · Jude Gomila · Wave 2 corpus-only joins applied · diff · file

Sources & links

ClinicalTrials.gov NCT04771130

Data

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Cancers

Acute myeloid leukaemia
Myelodysplastic syndromes / neoplasms (MDS)

Technologies

BCL-2 inhibitors
Small-molecule kinase inhibitors

Products

Sonrotoclax
Azacitidine

Companies

BeOne Medicines (formerly BeiGene)

Not yet reviewedNeeds expert (clinical) review. Review this page or see the review queue and roster.

Model panel commentary is coming to this page: machine commentary, not clinical review.

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