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Trials
PBSS1113 in Combination With Azacitidine to Treat Patients With AML/MDS

trialsTrialRecruiting

PBSS1113 in Combination With Azacitidine to Treat Patients With AML/MDS

A phase 1/2 trial of PBSS1113 in acute myeloid leukaemia and myelodysplastic syndromes / neoplasms, run by Chaser Therapeutics, Inc., now recruiting.

Overview Connected5

Overview

PBSS1113 in Combination With Azacitidine to Treat Patients With AML/MDS is a phase 1/2 interventional study registered as NCT07761533 by Chaser Therapeutics, Inc., with 29 participants planned, started 2025-09-08 and due to reach its primary completion in 2027-09. Interventions recorded: PBSS1113.

Setting

A Phase Ib/II, Open-Label, Dose-Escalation and Cohort Expansion Clinical Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Preliminary Efficacy of PBSS1113 in Combination With Azacitidine in Patients With Acute Myeloid Leukemia or Myelodysplastic Syndrome

Phase

Phase 1/2

Sponsor

Chaser Therapeutics, Inc.

Registry

Started

2025-09-08

Enrolled

29 enrolled

Connected

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cancers

Acute myeloid leukaemia Myelodysplastic syndromes / neoplasms (MDS)

technologies

Cytotoxic chemotherapy Epigenetic drugs (HDAC, DNMT, EZH2, IDH, menin, BET)

drugs

ApprovedSmall-molecule hypomethylating agent (cytotoxic)

Azacitidine · Vidaza / Onureg (oral)

Evidence strength20/100 · Preliminary

How much and what kind of evidence, not how big the benefit. Click for the breakdown.

Phase 1/2+8
29 enrolled+7
No structured primary endpoint0
Result: recruiting0
No independent replication recorded0
A linked product is approved+5

Formula disclosed on the evidence page.

ProvenanceLast edited 2026-09-22 · Jude Gomila · Wave 2 corpus-only joins applied · diff · file

Sources & links

ClinicalTrials.gov NCT07761533

Data

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Cancers

Acute myeloid leukaemia
Myelodysplastic syndromes / neoplasms (MDS)

Technologies

Cytotoxic chemotherapy
Epigenetic drugs (HDAC, DNMT, EZH2, IDH, menin, BET)

Products

Azacitidine

Not yet reviewedNeeds expert (clinical) review. Review this page or see the review queue and roster.

Model panel commentary is coming to this page: machine commentary, not clinical review.

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