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Trials
ADI-PEG 20 Plus Radiotherapy and Temozolomide in Subjects With Glioblastoma Multiforme

trialsTrialActive

ADI-PEG 20 Plus Radiotherapy and Temozolomide in Subjects With Glioblastoma Multiforme

A phase 2 trial of Temozolomide in glioma & glioblastoma, run by Polaris Group, active and no longer recruiting.

Overview Connected4

Overview

ADI-PEG 20 Plus Radiotherapy and Temozolomide in Subjects With Glioblastoma Multiforme is a phase 2 interventional study registered as NCT04587830 by Polaris Group, with 100 participants enrolled, started 2020-09-14 and due to reach its primary completion in 2027-02-28. Interventions recorded: ADI-PEG 20, Temozolomide and Placebo.

Setting

Phase 1-2 Trial of ADI-PEG 20 Plus Radiotherapy and Temozolomide in Subjects With Newly Diagnosed Glioblastoma Multiforme (GBM)

Phase

Phase 2

Sponsor

Polaris Group

Registry

Started

2020-09-14

Enrolled

100 enrolled

Connected

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cancers

Glioma & glioblastoma

technologies

Cytotoxic chemotherapy

drugs

ApprovedOral alkylating chemotherapy

Temozolomide · Temodar

companies

Evidence strength30/100 · Emerging

How much and what kind of evidence, not how big the benefit. Click for the breakdown.

Phase 2+15
100 enrolled+10
No structured primary endpoint0
Result: active0
No independent replication recorded0
A linked product is approved+5

Formula disclosed on the evidence page.

ProvenanceLast edited 2026-09-22 · Jude Gomila · Wave 2 corpus-only joins applied · diff · file

Sources & links

ClinicalTrials.gov NCT04587830

Data

JSON ·

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Cancers

Glioma & glioblastoma

Technologies

Cytotoxic chemotherapy

Products

Temozolomide

Companies

Polaris Group

Not yet reviewedNeeds expert (clinical) review. Review this page or see the review queue and roster.

Model panel commentary is coming to this page: machine commentary, not clinical review.

Machine-readable versions of ADI-PEG 20 Plus Radiotherapy and Temozolomide in Subjects With Glioblastoma Multiforme

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All trials as JSON
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MCP server: npx -y onco-mcp, tools search, get_entity, list_kind, ask, context, compare. This record is get_entity or context with id nct04587830.

WebMCP tools registered on this page: onco_search, onco_get_entity.