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Trials
A Study of Subcutaneous Blinatumomab Administration in Participants With R/R and MRD+ B-ALL

trialsTrialActive

A Study of Subcutaneous Blinatumomab Administration in Participants With R/R and MRD+ B-ALL

A phase 1/2 trial of Blinatumomab in acute lymphoblastic leukaemia, run by Amgen, active and no longer recruiting.

Overview Connected5

Overview

A Study of Subcutaneous Blinatumomab Administration in Participants With R/R and MRD+ B-ALL is a phase 1/2 interventional study registered as NCT04521231 by Amgen, with 181 participants enrolled, started 2021-01-04 and due to reach its primary completion in 2027-11-24. Interventions recorded: Blinatumomab.

Setting

A Phase 1/2 Open-label Study to Investigate the Safety, Efficacy, and Pharmacokinetics of Administration of Subcutaneous Blinatumomab for the Treatment of Adults and Adolescents With Relapsed or Refractory B Cell Precursor Acute Lymphoblastic Leukemia (R/R B-ALL) and Minimal Residual Disease Positive (MRD+) B-ALL

Phase

Phase 1/2

Sponsor

Amgen

Registry

Started

2021-01-04

Enrolled

181 enrolled

Connected

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cancers

Acute lymphoblastic leukaemia

technologies

T-cell engagers (bispecific)

drugs

ApprovedBispecific T-cell engager (CD19×CD3)

Blinatumomab · Blincyto

companies

Amgen BeOne Medicines (formerly BeiGene)

Evidence strength24/100 · Preliminary

How much and what kind of evidence, not how big the benefit. Click for the breakdown.

Phase 1/2+8
181 enrolled+11
No structured primary endpoint0
Result: active0
No independent replication recorded0
A linked product is approved+5

Formula disclosed on the evidence page.

ProvenanceLast edited 2026-09-22 · Jude Gomila · Wave 2 corpus-only joins applied · diff · file

Sources & links

ClinicalTrials.gov NCT04521231

Data

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Cancers

Acute lymphoblastic leukaemia

Technologies

T-cell engagers (bispecific)

Products

Blinatumomab

Companies

Amgen
BeOne Medicines (formerly BeiGene)

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