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Trials
Rollover Study to Provide Continued Treatment for Participants With B-Cell Malignancies Previously Enrolled in Studies of Parsaclisib (INCB050465)

trialsTrialActive

Rollover Study to Provide Continued Treatment for Participants With B-Cell Malignancies Previously Enrolled in Studies of Parsaclisib (INCB050465)

A phase 2 trial of Parsaclisib, Ruxolitinib and Ibrutinib in advanced solid tumours, run by Incyte Corporation, active and no longer recruiting.

Overview Connected5

Overview

Rollover Study to Provide Continued Treatment for Participants With B-Cell Malignancies Previously Enrolled in Studies of Parsaclisib (INCB050465) is a phase 2 interventional study registered as NCT04509700 by Incyte Corporation, with 112 participants enrolled, started 2020-08-03 and due to reach its primary completion in 2026-11-05. Interventions recorded: Parsaclisib, parsaclisib + itacitinib, parsaclisib + ruxolitinib and parsaclisib + ibrutinib.

Setting

A Phase 2, Open-Label, Multicenter, Rollover Study to Provide Continued Treatment for Participants With B-Cell Malignancies Previously Enrolled in Studies of Parsaclisib (INCB050465)

Phase

Phase 2

Sponsor

Incyte Corporation

Registry

Started

2020-08-03

Enrolled

112 enrolled

Connected

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cancers

Metastatic cancer (cancer that has spread)

drugs

ApprovedSmall-molecule covalent BTK inhibitor (first generation)

Ibrutinib · Imbruvica

Phase 2Oral PI3K inhibitor

ApprovedSmall-molecule JAK1/JAK2 inhibitor

Ruxolitinib · Jakafi / Jakavi

companies

Evidence strength30/100 · Emerging

How much and what kind of evidence, not how big the benefit. Click for the breakdown.

Phase 2+15
112 enrolled+10
No structured primary endpoint0
Result: active0
No independent replication recorded0
A linked product is approved+5

Formula disclosed on the evidence page.

ProvenanceLast edited 2026-09-16 · Jude Gomila · Registry trials wave 6 and products wave 7 · diff · file

Sources & links

ClinicalTrials.gov NCT04509700

Data

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Cancers

Metastatic cancer (cancer that has spread)

Products

Parsaclisib
Ruxolitinib
Ibrutinib

Companies

Incyte

Not yet reviewedNeeds expert (clinical) review. Review this page or see the review queue and roster.

Model panel commentary is coming to this page: machine commentary, not clinical review.

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