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INCB161734 is an experimental small-molecule drug from Incyte in phase 3 trials for pancreatic ductal adenocarcinoma, aimed at KRAS.
INCB161734 is a small-molecule drug developed by Incyte. Its target is KRAS (the sponsor names KRAS G12D). The sponsor states: An oral tablet identified on the trial page as a KRAS G12D inhibitor, evaluated in combination with standard chemotherapy (mFOLFIRINOX or GemNabP) versus chemotherapy alone in previously untreated, KRAS G12D-mutated metastatic pancreatic ductal adenocarcinoma. It is the investigational product in 1 recruiting or active industry-led phase 2 and phase 3 interventional cancer trial, including the phase 3 study NCT07522073 (A Study to Evaluate Chemotherapy With or Without INCB161734 in Previously Untreated, KRAS G12D-Mutated Metastatic Pancreatic Ductal Adenocarcinoma), in pancreatic ductal adenocarcinoma. The largest, NCT07522073, plans to enrol 588 participants with primary completion expected 2028-09-15. Status reflects the highest phase registered on ClinicalTrials.gov; no efficacy results are recorded here.
An oral tablet identified on the trial page as a KRAS G12D inhibitor, evaluated in combination with standard chemotherapy (mFOLFIRINOX or GemNabP) versus chemotherapy alone in previously untreated, KRAS G12D-mutated metastatic pancreatic ductal adenocarcinoma. Connects to KRAS.
1.INCB161734 slips into a pocket on KRAS.
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Query for this drug: (TITLE:"INCB161734" OR ABSTRACT:"INCB161734") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about INCB161734, not a curated reading list.
Shares Incyte and the tag pipeline.
Shares Incyte and the tag pipeline.
Shares KRAS and the tag pipeline.
Shares Pancreatic ductal adenocarcinoma and the tag pipeline.
Shares Incyte and the tag pipeline.
Shares KRAS, Pancreatic ductal adenocarcinoma and the tag pipeline.
Shares Pancreatic ductal adenocarcinoma and the tag pipeline.
Shares Pancreatic ductal adenocarcinoma and the tag pipeline.