Loading
Blood clots in the leg veins or lungs. Cancer makes blood clot more easily and some treatments (IMiDs, anti-VEGF drugs, hormone therapy, central lines, surgery) add risk; clots are the second commonest cause of death in cancer patients after the cancer itself.
Cancer-associated thrombosis affects 5-20% of patients, highest in pancreatic, gastric, brain and lung cancer and myeloma; the Khorana score identifies outpatients who benefit from prophylactic apixaban or rivaroxaban (AVERT, CASSINI). Treatment is a DOAC or low-molecular-weight heparin for at least 6 months, balancing bleeding risk in gastrointestinal and urothelial tumours. Lenalidomide and thalidomide mandate aspirin or anticoagulant prophylaxis; bevacizumab and other VEGF inhibitors raise arterial events; tamoxifen and erythropoiesis-stimulating agents raise venous ones. Incidental pulmonary emboli on staging CTs are common and are treated as symptomatic ones.
Showing the molecule this term concerns: Lenalidomide.
Shares When to seek urgent help with pancreatic cancer (NHS 111 and 999), Pancreatic ductal adenocarcinoma.
Shares Anti-VEGF class toxicities (hypertension, proteinuria, bleeding, perforation), Living with FOLFIRINOX, NALIRIFOX and gemcitabine with nab-paclitaxel, Pancreatic ductal adenocarcinoma.
Shares When to seek urgent help with pancreatic cancer (NHS 111 and 999), Pancreatic ductal adenocarcinoma.
Shares When to seek urgent help with pancreatic cancer (NHS 111 and 999), Pancreatic ductal adenocarcinoma.
Shares Immunomodulatory drugs (IMiDs) and CELMoDs, Lenalidomide.
Shares Thalidomide, Lenalidomide.
Shares When to seek urgent help with pancreatic cancer (NHS 111 and 999), Pancreatic ductal adenocarcinoma.
Shares Living with FOLFIRINOX, NALIRIFOX and gemcitabine with nab-paclitaxel, Pancreatic ductal adenocarcinoma.