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Sulfo-SPDB is a hindered disulfide linker that is stable in blood but is cut by the reducing environment inside cells, then converted to a membrane-crossing form.
Sulfo-SPDB attaches DM4 via a sterically hindered disulfide with a charged sulfonate that improves solubility and reduces aggregation. Intracellular glutathione reduces the bond; the released thiol is S-methylated into a neutral metabolite that diffuses to neighbouring cells. Used in mirvetuximab soravtansine.
Ball-and-stick model from PubChem 2D record (no 3D conformer available). PubChem record
Showing the molecule this term concerns: Mirvetuximab soravtansine.
Shares Mirvetuximab soravtansine, Antibody-drug conjugate (ADC).
Shares Mirvetuximab soravtansine, Antibody-drug conjugate (ADC).
Shares Mirvetuximab soravtansine, Antibody-drug conjugate (ADC).
Shares Mirvetuximab soravtansine, Antibody-drug conjugate (ADC).
Shares Mirvetuximab soravtansine, Antibody-drug conjugate (ADC).
Shares Mirvetuximab soravtansine, Antibody-drug conjugate (ADC).