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SMCC is the non-cleavable thioether linker in Kadcyla: the payload is freed only when the whole antibody is digested, so nothing leaks to neighbours.
SMCC is the non-cleavable thioether linker used in Kadcyla, also called MCC, and it frees its payload only when the whole antibody is digested, so nothing leaks to neighbouring cells. It couples DM1 to lysine residues on the antibody, and after lysosomal degradation the released species is lysine-SMCC-DM1, a charged catabolite that cannot cross membranes. The result is excellent plasma stability and low bystander killing, which is why T-DM1 needs high and homogeneous HER2 expression to work. The linker belongs to the Antibody-drug conjugate (ADC) technology and the Linker (ADC) term, is paired with the payload DM1, and is referenced by the drug record for Trastuzumab emtansine.
Showing the molecule this term concerns: Trastuzumab emtansine.
Shares Trastuzumab emtansine, Antibody-drug conjugate (ADC).
Shares Trastuzumab emtansine, Antibody-drug conjugate (ADC).
Shares Trastuzumab emtansine, Antibody-drug conjugate (ADC).
Shares Trastuzumab emtansine, Antibody-drug conjugate (ADC).