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The space at the back of the abdomen, behind the gut's lining, holding the kidneys, adrenals, pancreas, aorta and the para-aortic lymph nodes. Tumours here grow large before they are felt.
Retroperitoneal sarcomas (liposarcoma, leiomyosarcoma) are removed en bloc with adjacent organs and were the subject of the STRASS trials of preoperative radiotherapy; kidney, adrenal and pancreatic cancers are retroperitoneal organs. Para-aortic and retroperitoneal lymph nodes are staging sites for testicular, cervical, endometrial and gastric cancers, and retroperitoneal lymph node dissection remains part of testicular cancer treatment. Retroperitoneal spread often presents as back pain or ureteric obstruction.
Bone sarcomas favour the fast-growing ends of long bones (osteosarcoma) or the shaft (Ewing), soft tissue sarcomas the deep muscle compartments; spread is through the blood to the lungs, rarely via lymph nodes.
Lymph node spread is rare (except epithelioid, synovial, clear cell and rhabdomyosarcoma); sarcomas go through the blood to the lungs.
Same organ: Adamantinoma of bone, Dedifferentiated chordoma, Poorly differentiated chordoma (SMARCB1-deficient), Desmoplastic small round cell tumour, Leiomyosarcoma, Liposarcoma, Synovial sarcoma, Osteosarcoma, Ewing sarcoma, Rhabdomyosarcoma, Chordoma, Desmoid tumour, Tenosynovial giant cell tumour (TGCT), Epithelioid sarcoma, Vascular tumours (angiosarcoma, epithelioid haemangioendothelioma, kaposiform haemangioendothelioma), Chondrosarcoma, Angiosarcoma, Undifferentiated pleomorphic sarcoma (UPS), Myxofibrosarcoma, Alveolar soft part sarcoma, Perivascular epithelioid cell tumour (PEComa), Epithelioid haemangioendothelioma, Malignant peripheral nerve sheath tumour (MPNST), Retroperitoneal sarcoma, Soft tissue sarcoma of the extremity (localised and advanced)
Showing the organ this term concerns: Sarcomas (soft tissue, bone, GIST).
Shares Rosai-Dorfman-Destombes disease, Erdheim-Chester disease.
Shares Rosai-Dorfman-Destombes disease, Erdheim-Chester disease.
Shares Germ cell tumours of childhood and adolescence (extracranial and CNS), Testicular germ cell tumours.
Shares Rosai-Dorfman-Destombes disease, Erdheim-Chester disease, Erdheim-Chester disease, Rosai-Dorfman disease and other histiocytic neoplasms.
Shares Germ cell tumours of childhood and adolescence (extracranial and CNS), Testicular germ cell tumours.