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The Reed-Sternberg cell is the giant, often two-nucleus cancer cell of Hodgkin lymphoma; it makes up only about 1% of the tumour, and the rest is immune cells it has recruited.
Crippled germinal-centre B cells that have lost their B-cell programme, express CD30 and CD15, carry 9p24.1 (PD-L1/PD-L2) amplification in most cases, and are often EBV-positive. Their dependence on PD-L1 explains why Hodgkin lymphoma is the most checkpoint-inhibitor-responsive cancer (ORR ~70% for nivolumab or pembrolizumab in relapse).
In plain words · CD30 is a protein on the malignant Reed-Sternberg cells of Hodgkin lymphoma and on some T-cell lymphomas, and the address for the ADC brentuximab vedotin.
Showing the target this term concerns: CD30.
Shares Early-stage classical Hodgkin lymphoma (stage I to II), Advanced-stage classical Hodgkin lymphoma (stage III to IV), Hodgkin lymphoma.
Shares Relapsed and refractory classical Hodgkin lymphoma, Hodgkin lymphoma.
Shares Relapsed and refractory classical Hodgkin lymphoma, Hodgkin lymphoma.
Shares Relapsed and refractory classical Hodgkin lymphoma, Early-stage classical Hodgkin lymphoma (stage I to II), Advanced-stage classical Hodgkin lymphoma (stage III to IV), Hodgkin lymphoma.
Shares Relapsed and refractory classical Hodgkin lymphoma, Hodgkin lymphoma.
Shares Relapsed and refractory classical Hodgkin lymphoma, Early-stage classical Hodgkin lymphoma (stage I to II), Advanced-stage classical Hodgkin lymphoma (stage III to IV), Hodgkin lymphoma.
Shares CD30, Relapsed and refractory classical Hodgkin lymphoma, Hodgkin lymphoma.
Shares CD30, Early-stage classical Hodgkin lymphoma (stage I to II), Advanced-stage classical Hodgkin lymphoma (stage III to IV), Hodgkin lymphoma.