{"entity":{"id":"reed-sternberg-cell","kind":"term","name":"Reed-Sternberg cell","aka":["Reed-Sternberg cells"],"tldr":"The Reed-Sternberg cell is the giant, often two-nucleus cancer cell of Hodgkin lymphoma; it makes up only about 1% of the tumour, and the rest is immune cells it has recruited.","summary":"Crippled germinal-centre B cells that have lost their B-cell programme, express CD30 and CD15, carry 9p24.1 (PD-L1/PD-L2) amplification in most cases, and are often EBV-positive. Their dependence on PD-L1 explains why Hodgkin lymphoma is the most checkpoint-inhibitor-responsive cancer (ORR ~70% for nivolumab or pembrolizumab in relapse).","asOf":"2026-09-07","wikipedia":"https://en.wikipedia.org/wiki/Reed–Sternberg_cell","links":[{"label":"Wikipedia","url":"https://en.wikipedia.org/wiki/Reed–Sternberg_cell"}],"tags":[],"related":[],"cancers":["hodgkin-lymphoma"],"sections":[],"technologies":[],"targets":["cd30","pdl1"],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"category":"Cancer biology"},"route":"/terms/reed-sternberg-cell/","neighbours":{"cancer":[{"id":"advanced-stage-classical-hodgkin-lymphoma","kind":"cancer","name":"Advanced-stage classical Hodgkin lymphoma (stage III to IV)","route":"/cancers/advanced-stage-classical-hodgkin-lymphoma/"},{"id":"early-stage-classical-hodgkin-lymphoma","kind":"cancer","name":"Early-stage classical Hodgkin lymphoma (stage I to II)","route":"/cancers/early-stage-classical-hodgkin-lymphoma/"},{"id":"hodgkin-lymphoma","kind":"cancer","name":"Hodgkin lymphoma","route":"/cancers/hodgkin-lymphoma/"},{"id":"relapsed-refractory-hodgkin-lymphoma","kind":"cancer","name":"Relapsed and refractory classical Hodgkin lymphoma","route":"/cancers/relapsed-refractory-hodgkin-lymphoma/"}],"target":[{"id":"cd30","kind":"target","name":"CD30","route":"/targets/cd30/"},{"id":"pdl1","kind":"target","name":"PD-L1","route":"/targets/pdl1/"}]}}