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The space in the middle of the chest between the two lungs, containing the heart, great vessels, windpipe, food pipe and the lymph nodes that lung cancer spreads to first.
Whether mediastinal lymph nodes contain tumour separates stage I-II lung cancer (surgery first) from stage III (chemoradiation or neoadjuvant chemo-immunotherapy), so they are sampled by EBUS or mediastinoscopy before any operation. Thymomas, lymphomas and germ cell tumours arise in the mediastinum; oesophageal cancer and its nodes lie within it. On PET reports 'uptake above mediastinum' is the Deauville reference level.
Central tumours arise in the large airways, peripheral ones in the alveoli; both drain to hilar then mediastinal nodes, and the pleural lining is a separate cancer site.
Same organ: Mediastinal germ cell tumour, Pleuropulmonary blastoma (types I, Ir, II and III), Type A and type AB thymoma, Type B1 and type B2 thymoma, Type B3 thymoma, Micronodular thymoma with lymphoid stroma, Adenocarcinoma of the lung, Squamous cell carcinoma of the lung, Large cell carcinoma of the lung, Sarcomatoid carcinoma of the lung, Adenosquamous carcinoma of the lung, Invasive mucinous adenocarcinoma of the lung, Adenocarcinoma in situ and minimally invasive adenocarcinoma of the lung, Basaloid squamous cell carcinoma of the lung, Lymphoepithelial carcinoma of the lung, Pulmonary blastoma (adult), Lung cancer (all types), Small-cell lung cancer, Mesothelioma, Pleural mesothelioma, Thymoma and thymic carcinoma, Childhood lung and airway tumours (pleuropulmonary blastoma, tracheobronchial tumours), Inflammatory myofibroblastic tumour (IMT), EGFR-mutated non-small-cell lung cancer, ALK-positive non-small-cell lung cancer, KRAS G12C-mutant non-small-cell lung cancer, ROS1-positive non-small-cell lung cancer, MET exon 14 and MET-amplified non-small-cell lung cancer, RET fusion-positive non-small-cell lung cancer, BRAF V600E-mutant non-small-cell lung cancer, HER2-mutant non-small-cell lung cancer, NTRK fusion-positive non-small-cell lung cancer, PD-L1-high non-small-cell lung cancer without a driver mutation, Resectable stage I to III non-small-cell lung cancer, Unresectable stage III non-small-cell lung cancer, Limited-stage small-cell lung cancer, Extensive-stage small-cell lung cancer, Lung neuroendocrine tumours (typical and atypical carcinoid), Large cell neuroendocrine carcinoma of the lung, Thymoma (WHO types A, AB, B1, B2 and B3), Thymic carcinoma
Showing the organ this term concerns: Non-small-cell lung cancer.
Shares Endobronchial ultrasound (EBUS-TBNA), Mediastinal lymph node stations, Non-small-cell lung cancer.
Shares Endobronchial ultrasound (EBUS-TBNA), Mediastinal lymph node stations, Non-small-cell lung cancer.
Shares Endobronchial ultrasound (EBUS-TBNA), Mediastinal lymph node stations, Non-small-cell lung cancer.
Shares Bronchoscopy (EBUS, robotic navigation), Non-small-cell lung cancer.
Shares Unresectable stage III non-small-cell lung cancer, Non-small-cell lung cancer.
Shares Unresectable stage III non-small-cell lung cancer, Oesophageal cancer, Non-small-cell lung cancer.
Shares Superior vena cava obstruction, Non-small-cell lung cancer.
Shares Unresectable stage III non-small-cell lung cancer, Non-small-cell lung cancer.