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Stomach cancers come in two main shapes: intestinal (gland-forming, linked to H. pylori and HER2) and diffuse (scattered cells, linked to CDH1 loss and worse outcomes).
Intestinal type is more often HER2-positive, EBV- or MSI-associated, and arises via chronic gastritis; diffuse (signet-ring) type is CDH1-mutant, more common in younger patients and hereditary diffuse gastric cancer, poorly responsive to chemotherapy, and prone to peritoneal spread. The TCGA molecular classes (EBV, MSI, genomically stable, chromosomal instability) refine it.
Squamous cancers sit in the upper and middle oesophagus, adenocarcinomas at the junction and in the stomach; the stomach wall also gives rise to GIST from its pacemaker cells.
Same organ: HER2-positive gastric cancer, Claudin 18.2-positive gastric cancer, PD-L1-high gastric cancer, Microsatellite-unstable (MSI-high) gastric cancer, Early gastric cancer, Oesophageal squamous cell carcinoma, Oesophageal and junctional adenocarcinoma, Oesophageal cancer, Gastrointestinal stromal tumour (GIST), KIT exon 11-mutant GIST, PDGFRA D842V-mutant GIST, Imatinib-resistant GIST
Showing the organ this term concerns: Gastric & gastro-oesophageal junction cancer.