# Lauren classification (intestinal vs diffuse)

Source: https://onco.cc/terms/lauren-classification/  
OnCo record `lauren-classification` (Term). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

Stomach cancers come in two main shapes: intestinal (gland-forming, linked to H. pylori and HER2) and diffuse (scattered cells, linked to CDH1 loss and worse outcomes).

## Summary

Intestinal type is more often HER2-positive, EBV- or MSI-associated, and arises via chronic gastritis; diffuse (signet-ring) type is CDH1-mutant, more common in younger patients and hereditary diffuse gastric cancer, poorly responsive to chemotherapy, and prone to peritoneal spread. The TCGA molecular classes (EBV, MSI, genomically stable, chromosomal instability) refine it.

## Fields

- Kind: Term
- Last checked: 2026-09-07

## Sources

- Wikipedia: https://en.wikipedia.org/wiki/Gastric_cancer#Classification
- Wikipedia: https://en.wikipedia.org/wiki/Gastric_cancer#Classification

## Connected records

- cancers: [Gastric & gastro-oesophageal junction cancer](https://onco.cc/cancers/gastric/)

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