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Breast cancer cells confined inside the milk ducts, found mostly by mammography as calcifications. It is not life-threatening in itself, but around a third would progress to invasive cancer if left.
DCIS makes up 20-25% of screen-detected breast cancers. Standard treatment is lumpectomy with radiotherapy (or mastectomy for extensive disease) plus tamoxifen or an aromatase inhibitor if ER-positive; low-dose tamoxifen (5 mg, TAM-01) halves recurrence with fewer side effects. Because many DCIS lesions are indolent, active surveillance trials (COMET, LORIS, LORD) tested omitting surgery for low-risk disease, and COMET found no excess invasive cancer at 2 years. It is a leading example of the overdiagnosis debate in screening.
Showing the molecule this term concerns: Tamoxifen.
Shares Contrast-enhanced mammography, Breast MRI coils and abbreviated breast MRI, HR-positive / HER2-negative breast cancer.
Shares Ductal carcinoma in situ (DCIS), Tamoxifen, Breast cancer (all types), HR-positive / HER2-negative breast cancer.
Shares Carcinoma in situ (CIS), Ductal carcinoma in situ (DCIS), Tamoxifen, Breast cancer (all types).
Shares Contrast-enhanced mammography, Breast cancer (all types).
Shares Ductal carcinoma in situ (DCIS), Tamoxifen, Breast cancer (all types), HR-positive / HER2-negative breast cancer.
Shares Ductal carcinoma in situ (DCIS), Tamoxifen, Breast cancer (all types).
Shares Lumpectomy (breast-conserving surgery), Ductal carcinoma in situ (DCIS), Tamoxifen, Breast cancer (all types).
Shares Lumpectomy (breast-conserving surgery), Breast cancer (all types).