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Heart damage from cancer treatment: anthracyclines weaken the heart muscle permanently in a dose-related way, trastuzumab does so reversibly, and some kinase inhibitors raise blood pressure or disturb rhythm. Heart function (LVEF) is monitored by ultrasound during treatment.
Anthracycline cardiomyopathy risk rises steeply above 400-450 mg/m² doxorubicin and with radiotherapy or age; trastuzumab causes asymptomatic LVEF declines in 5-10% and heart failure in 1-4%, more after anthracyclines, monitored every 3 months and usually reversible on stopping. VEGF inhibitors cause hypertension and rarely heart failure; ibrutinib causes atrial fibrillation; immune checkpoint inhibitors cause rare fulminant myocarditis; androgen deprivation and aromatase inhibitors raise cardiovascular risk over years. Cardio-oncology clinics manage risk with ACE inhibitors, beta-blockers, statins and dexrazoxane; anthracycline-free regimens and non-anthracycline ADC payloads reduce exposure. Childhood cancer survivors carry lifelong cardiac risk.
Showing the molecule this term concerns: Doxorubicin.
Shares Escalated chemotherapy or ABVD in advanced Hodgkin lymphoma: more cures, more late harm, and what the interim scan changed, Early-stage classical Hodgkin lymphoma (stage I to II), Advanced-stage classical Hodgkin lymphoma (stage III to IV), Late effects and survivorship toxicity.
Shares Strain echocardiography (global longitudinal strain), Troponin and natriuretic peptide monitoring during cancer treatment, Cardio-oncology, Trastuzumab.
Shares Late effects of Hodgkin lymphoma treatment, and the follow-up that answers them, Relapsed and refractory classical Hodgkin lymphoma, Early-stage classical Hodgkin lymphoma (stage I to II), Advanced-stage classical Hodgkin lymphoma (stage III to IV).
Shares Relapsed and refractory classical Hodgkin lymphoma, Early-stage classical Hodgkin lymphoma (stage I to II), Advanced-stage classical Hodgkin lymphoma (stage III to IV), Late effects and survivorship toxicity.
Shares Escalated chemotherapy or ABVD in advanced Hodgkin lymphoma: more cures, more late harm, and what the interim scan changed, After Hodgkin lymphoma: the late effects, and the screening that follows them, Anthracyclines (doxorubicin, epirubicin), Late effects of Hodgkin lymphoma treatment, and the follow-up that answers them.
Shares Relapsed and refractory classical Hodgkin lymphoma, Ibrutinib, Early-stage classical Hodgkin lymphoma (stage I to II), Advanced-stage classical Hodgkin lymphoma (stage III to IV).
Shares Relapsed and refractory classical Hodgkin lymphoma, Early-stage classical Hodgkin lymphoma (stage I to II), Advanced-stage classical Hodgkin lymphoma (stage III to IV), Hodgkin lymphoma.
Shares Cardio-oncology, Doxorubicin, Hodgkin lymphoma, Diffuse large B-cell lymphoma.