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A Y-shaped protein the immune system makes to grab onto one specific target. Manufactured antibodies are now a cornerstone of cancer treatment, either blocking a protein or delivering a payload to it.
Each antibody's two arm tips bind one specific antigen with great precision, while its stem (the Fc region) can recruit immune cells and complement or extend the antibody's life in the blood. Therapeutic antibodies block growth receptors (trastuzumab on HER2, cetuximab on EGFR), release the brakes on T cells (pembrolizumab on PD-1), flag cancer cells for immune killing (rituximab on CD20), or serve as the targeting vehicle of ADCs and radioimmunotherapy. Bispecific antibodies have two different arm tips and can physically pull a T cell onto a tumour cell.
Backbone ribbon from PDB 1N8Z. RCSB PDB 1N8Z. The ribbon widens where the chain is folded into a regular pattern and narrows where it is a loose loop.
Showing the molecule this term concerns: Trastuzumab.
Shares Trastuzumab, Monoclonal antibodies, Antibody-drug conjugate (ADC), Pembrolizumab.
Shares Trastuzumab, Monoclonal antibodies, Antibody-drug conjugate (ADC), Pembrolizumab.
Shares Trastuzumab, Monoclonal antibodies, Antibody-drug conjugate (ADC), Pembrolizumab.
Shares Trastuzumab, Monoclonal antibodies, Antibody-drug conjugate (ADC), Pembrolizumab.
Shares Trastuzumab, Monoclonal antibodies, Pembrolizumab, Immune checkpoint inhibitors.
Shares Fc engineering / effector function, ADCC (antibody-dependent cellular cytotoxicity), Monoclonal antibodies.
Shares Fc engineering / effector function, ADCC (antibody-dependent cellular cytotoxicity), Bispecific antibodies, Trastuzumab.