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CZI's open cross-species cell models and a reasoning model trained on them.
TranscriptFormer is the Chan Zuckerberg Initiative's open generative transformer over single cells, trained on 112M cells across 12 species so it can compare cell states across organisms. Its companion rBio uses the outputs of virtual cell models as a teacher to train a language model that reasons about gene perturbations in plain language, a distillation of a simulator into a conversational model. Both are released through the CZI Virtual Cells Platform and are intended for biologists who want open, cross-species tools rather than proprietary ones. The work is early, published in 2025, and independent evaluation of how well rBio's reasoning tracks experimental results is still to come. For a newcomer: these are free models from CZI that map cells across species and let you ask a chatbot what a gene knockout might do.
TranscriptFormer is a generative transformer over cells, distilled into an LLM.
Query for this technology: (TITLE:"TranscriptFormer and rBio" OR ABSTRACT:"TranscriptFormer and rBio" OR TITLE:"CZI virtual cell models" OR ABSTRACT:"CZI virtual cell models") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about TranscriptFormer and rBio (CZI virtual cell models), not a curated reading list.
Shares Chan Zuckerberg Initiative (Biohub), Virtual cell roadmap: from bulk omics to a predictive model of a cancer cell and the tags foundation-model, virtual-cell.
Shares Virtual cell roadmap: from bulk omics to a predictive model of a cancer cell and the tags foundation-model, virtual-cell.
Shares Virtual cell roadmap: from bulk omics to a predictive model of a cancer cell and the tags foundation-model, virtual-cell.
Shares Virtual cell roadmap: from bulk omics to a predictive model of a cancer cell and the tags foundation-model, virtual-cell.
Shares Virtual cell roadmap: from bulk omics to a predictive model of a cancer cell and the tags foundation-model, virtual-cell.
Shares Virtual cell roadmap: from bulk omics to a predictive model of a cancer cell and the tags foundation-model, virtual-cell.
Shares Virtual cell roadmap: from bulk omics to a predictive model of a cancer cell and the tags foundation-model, virtual-cell.
Shares the tags foundation-model, virtual-cell.
Open-source projects that implement or serve this technology, from OnCo's own catalogue: licence and last activity as the repository reported them on the day of the fetch. Listing is not endorsement; check the licence before reuse and the validation before clinical use.
CZI's cross-species generative single-cell foundation model.