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Thyroid fine-needle aspiration takes a needle sample from a thyroid lump and grades it on a six-level scale; when the result is uncertain, a gene test on the same sample can often rule cancer out and avoid surgery.
Ultrasound-guided fine-needle aspiration reported by the Bethesda System (I-VI). Indeterminate categories (III-IV, ~20% of nodules) historically went to diagnostic lobectomy; molecular classifiers such as Afirma GSC (RNA expression, Veracyte) and ThyroSeq v3 (DNA/RNA NGS) have negative predictive values around 95-97%, halving unnecessary surgery. TI-RADS ultrasound scoring decides which nodules to biopsy at all.
Cytology is combined with gene-expression or mutation/fusion panels calibrated on surgical outcomes.
A gene test on the needle sample from a thyroid lump that can safely call an 'uncertain' result benign and spare an operation.
Query for this technology: (TITLE:"Thyroid nodule FNA, Bethesda cytology & molecular classifiers" OR ABSTRACT:"Thyroid nodule FNA, Bethesda cytology & molecular classifiers") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Thyroid nodule FNA, Bethesda cytology & molecular classifiers, not a curated reading list.
Shares Ultrasound restraint and surveillance to reverse thyroid cancer overdiagnosis, Ultrasound, Overdiagnosis and false alarms, Thyroid cancer.
Shares Ultrasound restraint and surveillance to reverse thyroid cancer overdiagnosis, Overdiagnosis and false alarms.
Shares Ultrasound, Overdiagnosis and false alarms, Thyroid cancer.
Shares Veracyte (Decipher), RNA sequencing & expression profiling.
Shares Veracyte (Decipher), RNA sequencing & expression profiling.
Shares Thyroglobulin, calcitonin and CEA in thyroid cancer follow-up, Thyroid cancer.
Shares Ultrasound, Overdiagnosis and false alarms, Thyroid cancer.