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The tubes and fixatives that keep a sample stable between the patient and the lab. Unglamorous, but they decide whether a liquid biopsy or PD-L1 stain is trustworthy.
Cell-free DNA stabilising tubes (Streck Cell-Free DNA BCT, PAXgene ccfDNA, Roche Cell-Free DNA Collection Tube) allow ctDNA to be shipped at room temperature for days; formalin fixation time and ischaemia time affect IHC scoring and nucleic-acid quality (CAP/CLSI and ASCO/CAP HER2 guidelines set 6-72 hour fixation windows); RNAlater and vacuum-sealed transport are alternatives. Pre-analytic variability is a major source of discordant biomarker results.
Chemical stabilisers prevent leukocyte lysis and nuclease activity in blood; cross-linking fixation preserves morphology and antigens in tissue within validated time windows.
Nothing recorded yet: a foundation, or a gap to fill.
Dependencies are what this technology cannot be delivered without: manufacturing steps, instruments, software, upstream methods. See its full chain on the map.
Query for this technology: (TITLE:"Pre-analytics: blood-collection tubes and tissue fixation" OR ABSTRACT:"Pre-analytics: blood-collection tubes and tissue fixation") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Pre-analytics: blood-collection tubes and tissue fixation, not a curated reading list.
Shares Reference laboratories and companion-diagnostic testing, Histopathology & immunohistochemistry and the tag supporting.
Shares Biobanking and tissue procurement and the tag supporting.
Shares Reference laboratories and companion-diagnostic testing, Histopathology & immunohistochemistry, Roche / Genentech and the tag supporting.
Shares Reference laboratories and companion-diagnostic testing, Histopathology & immunohistochemistry and the tag supporting.
Shares Biobanking and tissue procurement and the tag supporting.
Shares Reference laboratories and companion-diagnostic testing and the tag supporting.
Shares Biobanking and tissue procurement and the tag supporting.
Shares Reference laboratories and companion-diagnostic testing and the tag supporting.