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Sequencing several parts of a tumour, or blood over time, to draw its family tree of mutations and see which branches drive relapse and resistance.
Multi-region and longitudinal sequencing reconstruct a tumour's subclonal architecture and phylogeny. Studies such as TRACERx in lung cancer showed that chromosomal instability and subclonal expansion predict relapse, and that circulating tumour DNA can track which clones survive treatment. The concepts of truncal versus branch mutations shape target selection: a drug against a truncal mutation hits every cell, one against a branch mutation hits only a subclone.
Sequence multiple tumour regions or serial plasma samples, cluster mutations by cellular fraction, and build phylogenetic trees that order events and quantify heterogeneity.
Query for this technology: (TITLE:"Tumour clonal evolution tracking" OR ABSTRACT:"Tumour clonal evolution tracking") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Tumour clonal evolution tracking, not a curated reading list.
Shares Goldie-Coldman model of resistance, Evolutionary dynamics of drug resistance, Evolutionary game theory in cancer, Clonal evolution and branching models.
Shares Tumour evolution (somatic evolution), Evolutionary game theory in cancer, Clonal evolution and branching models, Adaptive therapy (evolution-based dosing).
Shares Clonal evolution and branching models, Metastatic seeding and dormancy models, MRD / molecular residual disease testing, Liquid biopsy (ctDNA).
Open-source projects that implement or serve this technology, from OnCo's own catalogue: licence and last activity as the repository reported them on the day of the fetch. Listing is not endorsement; check the licence before reuse and the validation before clinical use.
Haplotype-aware copy-number and clonal phylogeny inference from single-cell transcriptomes.
Bayesian clustering of somatic mutations into clonal populations from allele frequencies, a standard tool for tumour clonal architecture.
Clusters variants by allele frequency to reveal the clonal structure of a tumour, from the McDonnell Genome Institute.
Calls germline and somatic variants from single-cell sequencing data to trace clonal lineages, from MD Anderson.
Reconstructs the evolutionary tree of subclones in a tumour from whole-genome variant and copy-number data.
A faster variational-inference successor to PyClone for clonal population inference on large datasets.
Infers clone trees from many samples of the same cancer, scaling to dozens of subclones.
Assigns single-cell expression profiles to clones defined by single-cell DNA copy number.