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Peter Nowell's 1976 idea that a tumour is an evolving population of competing clones is now measured directly by sequencing several regions or repeated blood samples, and models of branching evolution predict which clones will drive relapse.
Nowell proposed that tumours arise from a single cell and evolve by mutation and selection into a branching tree of clones. Multi-region sequencing (TRACERx in lung cancer, from 2017) and longitudinal circulating tumour DNA confirmed branched evolution, showed truncal versus subclonal mutations, and revealed that some tumours evolve neutrally while others show strong selective sweeps. Models built on these data estimate mutation rates, timing of metastasis and the likelihood that a subclone carries resistance, and inform which mutations to target (truncal) and how to read residual disease.
A tumour is a population under mutation, drift and selection; phylogenetic and branching-process models reconstruct its history from the variant allele frequencies observed across regions and time.
Query for this technology: (TITLE:"Clonal evolution and branching models" OR ABSTRACT:"Clonal evolution and branching models") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Clonal evolution and branching models, not a curated reading list.
Shares Tumour clonal evolution tracking, Continuous and near-continuous ctDNA monitoring, Mathematical models of cancer (mathematical oncology), Whole-exome & whole-genome sequencing and the tag mathematical-model.
Shares Tumour clonal evolution tracking, Mathematical models of cancer (mathematical oncology), Whole-exome & whole-genome sequencing and the tag mathematical-model.
Shares Tumour clonal evolution tracking, Mathematical models of cancer (mathematical oncology), Clonal evolution and the ecological view of cancer, Whole-exome & whole-genome sequencing and the tag mathematical-model.
Shares Tumour clonal evolution tracking, Mathematical models of cancer (mathematical oncology), Clonal evolution and the ecological view of cancer and the tag mathematical-model.
Shares Tumour clonal evolution tracking, Mathematical models of cancer (mathematical oncology) and the tag mathematical-model.
Shares Continuous and near-continuous ctDNA monitoring, Mathematical models of cancer (mathematical oncology), Non-small-cell lung cancer and the tag mathematical-model.
Shares Mathematical models of cancer (mathematical oncology), Renal cell carcinoma, Non-small-cell lung cancer and the tag mathematical-model.
Shares Mathematical models of cancer (mathematical oncology), Non-small-cell lung cancer and the tag mathematical-model.
Open-source projects that implement or serve this technology, from OnCo's own catalogue: licence and last activity as the repository reported them on the day of the fetch. Listing is not endorsement; check the licence before reuse and the validation before clinical use.
Subclonal deconvolution that models neutral tail mutations explicitly, so evolutionary dynamics are separated from clonal clusters.
