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Cannabis and cannabinoids are used by patients for pain, appetite and sleep. Three phase 3 trials of a THC:CBD mouth spray added to opioids did not beat placebo for cancer pain, dronabinol failed for appetite, and no human trial shows tumour control, so ASCO's 2024 guideline advises against them as cancer treatment outside a trial.
Three randomised placebo-controlled phase 3 trials of nabiximols (THC:CBD oromucosal spray) added to optimised opioids for advanced cancer pain (Fallon et al. 2017; Lichtman et al. 2018) failed to meet their primary endpoints, and dronabinol did not improve appetite or weight in a randomised trial against megestrol acetate. Observational surveys report benefit for sleep and wellbeing but cannot separate expectation. Preclinical antitumour activity of cannabinoids in glioma and other models has not been followed by any positive human efficacy trial, and CBD oils sold online vary widely in content. The 2024 ASCO guideline recommends that clinicians should not recommend cannabis or cannabinoids to treat cancer except in a clinical trial, notes low-certainty evidence for pain and sleep, and flags interactions: CBD inhibits CYP2C19 and CYP3A4, and observational data suggest cannabis users may respond less well to checkpoint immunotherapy, an unconfirmed but concerning signal. Legal status and product quality vary by country.
CB1 and CB2 receptor agonism modulates nociception, appetite and mood; in tumour models cannabinoids induce apoptosis and inhibit angiogenesis at concentrations not achieved in patients.
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One technology page on OnCo cites this paper by its DOI; this record gives the citation a page of its own so a reader can follow it without leaving OnCo. Read the abstract above alongside the citing page listed under Related; the record was created automatically from the Europe PMC entry and its figures have not been checked by hand.
Query for this technology: (TITLE:"Cannabis and cannabinoids for pain, appetite and cancer control" OR ABSTRACT:"Cannabis and cannabinoids for pain, appetite and cancer control") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Cannabis and cannabinoids for pain, appetite and cancer control, not a curated reading list.
Shares Dietary supplements during cancer treatment: interactions and harms, Evidence-based integrative oncology, Misinformation and unproven therapies and the tags complementary, supportive-care.
Shares Dietary supplements during cancer treatment: interactions and harms, Evidence-based integrative oncology, Misinformation and unproven therapies and the tags complementary, supportive-care.
Shares Dietary supplements during cancer treatment: interactions and harms, Evidence-based integrative oncology, Misinformation and unproven therapies and the tags complementary, supportive-care.
Shares Dietary supplements during cancer treatment: interactions and harms, Evidence-based integrative oncology, Misinformation and unproven therapies and the tags complementary, supportive-care.
Shares Dietary supplements during cancer treatment: interactions and harms, Evidence-based integrative oncology, Misinformation and unproven therapies and the tags complementary, supportive-care.
Shares Dietary supplements during cancer treatment: interactions and harms, Evidence-based integrative oncology, Misinformation and unproven therapies and the tags complementary, supportive-care.
Shares Cancer pain management, Pain relief and palliative care are unavailable to most, Evidence-based integrative oncology and the tags complementary, supportive-care.
Shares Dietary supplements during cancer treatment: interactions and harms, Evidence-based integrative oncology, Misinformation and unproven therapies and the tags complementary, supportive-care.