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Instead of equations for average behaviour, agent-based models simulate every cell as an individual with rules for dividing, moving, dying and signalling, producing virtual tumours in which immune attack, drug delivery and evolution can be watched and tested.
Agent-based models represent thousands to millions of cells as discrete agents on a lattice or in continuous space, each following rules drawn from biology, with diffusing chemicals such as oxygen and drugs computed alongside. Open frameworks such as PhysiCell and CompuCell3D and the Anderson-Chaplain and Rejniak lineages have simulated tumour growth under hypoxia, immune infiltration, nanoparticle delivery and the emergence of invasive phenotypes. They are the natural tool for testing adaptive therapy schedules and spatial hypotheses, at the cost of many parameters and heavy computation.
Discrete cells with rule-based behaviour interact with each other and with continuous fields of nutrients and drugs; population behaviour emerges rather than being assumed.
Query for this technology: (TITLE:"Agent-based and multicellular simulations" OR ABSTRACT:"Agent-based and multicellular simulations") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Agent-based and multicellular simulations, not a curated reading list.
Shares Digital twins and virtual control arms, Mathematical models of cancer (mathematical oncology) and the tag mathematical-model.
Shares AI compute and model platforms for oncology, Mathematical models of cancer (mathematical oncology) and the tag mathematical-model.
Shares Digital twins and virtual control arms, Mathematical models of cancer (mathematical oncology) and the tag mathematical-model.
Shares Mathematical models of cancer (mathematical oncology) and the tag mathematical-model.
Shares Mathematical models of cancer (mathematical oncology) and the tag mathematical-model.
Shares Mathematical models of cancer (mathematical oncology) and the tag mathematical-model.
Shares Mathematical models of cancer (mathematical oncology) and the tag mathematical-model.
Shares Mathematical models of cancer (mathematical oncology) and the tag mathematical-model.
Open-source projects that implement or serve this technology, from OnCo's own catalogue: licence and last activity as the repository reported them on the day of the fetch. Listing is not endorsement; check the licence before reuse and the validation before clinical use.
An agent-based simulator of cells and tissues used to model tumour growth, immune attack and drug response in silico.
A high-performance agent-based simulation platform from CERN openlab and collaborators, applied to tumour growth models.
Multi-cell modelling with the Cellular Potts approach, used in tumour and angiogenesis simulations.
A Java library from Moffitt's Integrated Mathematical Oncology department for hybrid agent-based and PDE tumour models.