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ZNF429 (Zinc finger protein 429) is a protein that switches other genes on and off. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Bladder & urothelial cancer, Hepatocellular carcinoma, Prostate cancer and 1 more.
May be involved in transcriptional regulation.
Open Targets scores its association with cancer at 0.51 (direct and indirect evidence; datatypes literature 0.17, genetic association 0.00, somatic mutation 0.66). IntOGen calls it a driver in 4 cohorts (1 activating, 2 loss-of-function), covering Bladder Urothelial Carcinoma, Cholangiocarcinoma, Hepatocellular Carcinoma, Prostate Adenocarcinoma.
In plain words · ZNF429 (Zinc finger protein 429) is a protein that switches other genes on and off. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Bladder & urothelial cancer, Hepatocellular carcinoma, Prostate cancer and 1 more.
ZNF429 (Zinc finger protein 429) is a protein that switches other genes on and off. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Bladder & urothelial cancer, Hepatocellular carcinoma, Prostate cancer and 1 more.
May be involved in transcriptional regulation. Location: Nucleus (UniProt).
No product in this corpus aims at ZNF429 yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
First described 1995. Earliest sequence paper UniProt cites for the protein: Abrink et al, DNA Cell Biol, 1995, "Isolation of cDNA clones for 42 different Kruppel-related zinc finger proteins expressed in the human monoblast cell line U-937". Source.
Sources: HGNC HGNC:20817 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q86V71 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000197013 (association with cancer (MONDO_0004992) 0.51; (GraphQL API, CC0)); IntOGen ZNF429 (driver in 4 cohorts (Act 1, LoF 2); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
May be involved in transcriptional regulation. Location: Nucleus (UniProt). Locus 19p12 (HGNC).
Query for this target: (TITLE:"ZNF429" OR ABSTRACT:"ZNF429" OR TITLE:"zinc finger protein 429" OR ABSTRACT:"zinc finger protein 429" OR TITLE:"Zinc finger protein 429" OR ABSTRACT:"Zinc finger protein 429") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about ZNF429, not a curated reading list.