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ZFHX4 (Zinc finger homeobox protein 4) is a protein that switches other genes on and off. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role.
May play a role in neural and muscle differentiation. May be involved in transcriptional regulation.
Open Targets scores its association with cancer at 0.51 (direct and indirect evidence; datatypes literature 0.92, animal model 0.43, genetic association 0.63).
In plain words · ZFHX4 (Zinc finger homeobox protein 4) is a protein that switches other genes on and off. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role.
ZFHX4 (Zinc finger homeobox protein 4) is a protein that switches other genes on and off. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role.
May play a role in neural and muscle differentiation. May be involved in transcriptional regulation.
No product in this corpus aims at ZFHX4 yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
First described 2003. Earliest sequence paper UniProt cites for the protein: Shan Y.X. et al, 2003. Source.
Sources: HGNC HGNC:30939 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q86UP3 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000091656 (association with cancer (MONDO_0004992) 0.51; (GraphQL API, CC0))
May play a role in neural and muscle differentiation. May be involved in transcriptional regulation. Location: Nucleus (UniProt). Locus 8q21.13 (HGNC).
Query for this target: (TITLE:"ZFHX4" OR ABSTRACT:"ZFHX4" OR TITLE:"zinc finger homeobox 4" OR ABSTRACT:"zinc finger homeobox 4" OR TITLE:"Zinc finger homeobox protein 4" OR ABSTRACT:"Zinc finger homeobox protein 4" OR TITLE:"ZFH4" OR ABSTRACT:"ZFH4" OR TITLE:"FLJ20980" OR ABSTRACT:"FLJ20980") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about ZFHX4, not a curated reading list.