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YWHAE (14-3-3 protein epsilon) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Sarcomas.
Adapter protein implicated in the regulation of a large spectrum of both general and specialised signalling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.
Open Targets scores its association with cancer at 0.63 (direct and indirect evidence; datatypes literature 0.94, genetic association 0.00, somatic mutation 0.98).
In plain words · YWHAE (14-3-3 protein epsilon) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Sarcomas.
YWHAE (14-3-3 protein epsilon) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Sarcomas.
Adapter protein implicated in the regulation of a large spectrum of both general and specialised signalling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif.
No product in this corpus aims at YWHAE yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
First described 1991. Earliest sequence paper UniProt cites for the protein: Demeter et al, Immunology, 1991, "Isolation and partial characterization of the structures of fibroblast activating factor-related proteins from U937 cells". Source.
Sources: HGNC HGNC:12851 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P62258 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000108953 (association with cancer (MONDO_0004992) 0.63; per-cancer scores at or above 0.5: sarcoma 0.59 (GraphQL API, CC0))
Adapter protein implicated in the regulation of a large spectrum of both general and specialised signalling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Positively regulates phosphorylated protein HSF1 nuclear export to the cytoplasm. Plays a positive role in the antiviral signalling pathway upstream of TBK1 via interaction with RIGI. Mechanistically, directs RIGI redistribution from the cytosol to mitochondrial associated membranes where it mediates MAVS-dependent innate immune signalling during viral infection. Location: Nucleus; Cytoplasm; Melanosome (UniProt). Locus 17p13.3 (HGNC).
Query for this target: (TITLE:"YWHAE" OR ABSTRACT:"YWHAE" OR TITLE:"tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon" OR ABSTRACT:"tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon" OR TITLE:"14-3-3 protein epsilon" OR ABSTRACT:"14-3-3 protein epsilon" OR TITLE:"FLJ45465" OR ABSTRACT:"FLJ45465") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about YWHAE, not a curated reading list.