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YWHAB (14-3-3 protein beta/alpha) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Adapter protein implicated in the regulation of a large spectrum of both general and specialised signalling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.
Open Targets scores its association with cancer at 0.62 (direct and indirect evidence; datatypes literature 0.92, affected pathway 0.97, animal model 0.30, genetic association 0.00).
In plain words · YWHAB (14-3-3 protein beta/alpha) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
YWHAB (14-3-3 protein beta/alpha) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Adapter protein implicated in the regulation of a large spectrum of both general and specialised signalling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif.
No product in this corpus aims at YWHAB yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
First described 1993. Earliest sequence paper UniProt cites for the protein: Leffers et al, J. Mol. Biol, 1993, "Molecular cloning and expression of the transformation sensitive epithelial marker stratifin. A member of a protein family that has been involved in the protein kinase C signalling pathway". Source.
Sources: HGNC HGNC:12849 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P31946 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000166913 (association with cancer (MONDO_0004992) 0.62; (GraphQL API, CC0))
Adapter protein implicated in the regulation of a large spectrum of both general and specialised signalling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negative regulator of osteogenesis. Blocks the nuclear translocation of the phosphorylated form (by AKT1) of SRPK2 and antagonises its stimulatory effect on cyclin D1 expression resulting in blockage of neuronal apoptosis elicited by SRPK2. Negative regulator of signalling cascades that mediate activation of MAP kinases via AKAP13. Location: Cytoplasm; Melanosome; Vacuole membrane (UniProt). Locus 20q13.12 (HGNC).
Query for this target: (TITLE:"YWHAB" OR ABSTRACT:"YWHAB" OR TITLE:"tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta" OR ABSTRACT:"tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta" OR TITLE:"14-3-3 protein beta/alpha" OR ABSTRACT:"14-3-3 protein beta/alpha" OR TITLE:"YWHAA" OR ABSTRACT:"YWHAA") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about YWHAB, not a curated reading list.