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XPC (DNA repair protein complementing XP-C cells) is a protein that switches other genes on and off. The public catalogues list it as a DNA repair gene, and the evidence so far is association rather than a proven role. Tied to Lung cancer and Prostate cancer.
Involved in global genome nucleotide excision repair (GG-NER) by acting as damage sensing and DNA-binding factor component of the XPC complex. Has only a low DNA repair activity by itself which is stimulated by RAD23B and RAD23A. Has a preference to bind DNA containing a short single-stranded segment but not to damaged oligonucleotides.
Open Targets scores its association with cancer at 0.70 (direct and indirect evidence; datatypes literature 0.98, animal model 0.71, genetic association 0.62, somatic mutation 0.93).
In plain words · XPC (DNA repair protein complementing XP-C cells) is a protein that switches other genes on and off. The public catalogues list it as a DNA repair gene, and the evidence so far is association rather than a proven role. Tied to Lung cancer and Prostate cancer.
XPC (DNA repair protein complementing XP-C cells) is a protein that switches other genes on and off. The public catalogues list it as a DNA repair gene, and the evidence so far is association rather than a proven role. Tied to Lung cancer and Prostate cancer.
Involved in global genome nucleotide excision repair (GG-NER) by acting as damage sensing and DNA-binding factor component of the XPC complex. Has only a low DNA repair activity by itself which is stimulated by RAD23B and RAD23A.
No product in this corpus aims at XPC yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
First described 1992. Earliest sequence paper UniProt cites for the protein: Legerski R.J. et al, Nature, 1992, "Expression cloning of a human DNA repair gene involved in Xeroderma pigmentosum group C". Source.
Sources: HGNC HGNC:12816 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q01831 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000154767 (association with cancer (MONDO_0004992) 0.70; per-cancer scores at or above 0.5: prostate cancer 0.53, lung cancer 0.54 (GraphQL API, CC0))
Involved in global genome nucleotide excision repair (GG-NER) by acting as damage sensing and DNA-binding factor component of the XPC complex. Has only a low DNA repair activity by itself which is stimulated by RAD23B and RAD23A. Has a preference to bind DNA containing a short single-stranded segment but not to damaged oligonucleotides. This feature is proposed to be related to a dynamic sensor function: XPC can rapidly screen duplex DNA for non-hydrogen-bonded bases by forming a transient nucleoprotein intermediate complex which matures into a stable recognition complex through an intrinsic single-stranded DNA-binding activity. The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, XPA, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex. The XPC complex recognises a wide spectrum of damaged DNA characterised by distortions of the DNA helix such as single-stranded loops, mismatched bubbles or single-stranded overhangs. Location: Nucleus; Chromosome; Cytoplasm (UniProt). Locus 3p25.1 (HGNC).
Query for this target: (TITLE:"XPC" OR ABSTRACT:"XPC" OR TITLE:"XPC complex subunit, DNA damage recognition and repair factor" OR ABSTRACT:"XPC complex subunit, DNA damage recognition and repair factor" OR TITLE:"DNA repair protein complementing XP-C cells" OR ABSTRACT:"DNA repair protein complementing XP-C cells" OR TITLE:"RAD4" OR ABSTRACT:"RAD4") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about XPC, not a curated reading list.