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WWOX (WW domain-containing oxidoreductase) is an enzyme. In the public catalogues the evidence so far is association rather than a proven role. Tied to Oesophageal cancer.
Putative oxidoreductase. Acts as a tumour suppressor and plays a role in apoptosis. Required for normal bone development.
Open Targets scores its association with cancer at 0.64 (direct and indirect evidence; datatypes genetic literature 0.30, literature 0.98, genetic association 0.76, somatic mutation 0.55, animal model 0.49).
In plain words · WWOX (WW domain-containing oxidoreductase) is an enzyme. In the public catalogues the evidence so far is association rather than a proven role. Tied to Oesophageal cancer.
WWOX (WW domain-containing oxidoreductase) is an enzyme. In the public catalogues the evidence so far is association rather than a proven role. Tied to Oesophageal cancer.
Putative oxidoreductase. Acts as a tumour suppressor and plays a role in apoptosis.
No product in this corpus aims at WWOX yet. Inhibitors are shaped to fit the enzyme's active site so the reaction the cancer relies on stops.
First described 2000. Earliest sequence paper UniProt cites for the protein: Bednarek A.K. et al, Cancer Res, 2000, "WWOX, a novel WW domain-containing protein mapping to human chromosome 16q23.3-24.1, a region frequently affected in breast cancer". Source.
Sources: HGNC HGNC:12799 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q9NZC7 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000186153 (association with cancer (MONDO_0004992) 0.64; per-cancer scores at or above 0.5: oesophageal cancer 0.62 (GraphQL API, CC0))
Putative oxidoreductase. Acts as a tumour suppressor and plays a role in apoptosis. Required for normal bone development. May function synergistically with p53/TP53 to control genotoxic stress-induced cell death. Plays a role in TGFB1 signalling and TGFB1-mediated cell death. May also play a role in tumour necrosis factor (TNF)-mediated cell death. Location: Cytoplasm; Nucleus; Mitochondrion; Golgi apparatus (UniProt). Locus 16q23.1-q23.2 (HGNC).
Query for this target: (TITLE:"WWOX" OR ABSTRACT:"WWOX" OR TITLE:"WW domain containing oxidoreductase" OR ABSTRACT:"WW domain containing oxidoreductase" OR TITLE:"WW domain-containing oxidoreductase" OR ABSTRACT:"WW domain-containing oxidoreductase" OR TITLE:"WOX1" OR ABSTRACT:"WOX1" OR TITLE:"SDR41C1" OR ABSTRACT:"SDR41C1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about WWOX, not a curated reading list.