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WDR12 (Ribosome biogenesis protein WDR12) is a gene. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Glioma & glioblastoma.
Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.
CIViC holds 1 clinical evidence item and 0 assertions across 1 variant.
In plain words · WDR12 (Ribosome biogenesis protein WDR12) is a gene. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Glioma & glioblastoma.
WDR12 (Ribosome biogenesis protein WDR12) is a gene. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Glioma & glioblastoma.
Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome. Location: Nucleus, nucleolus; Nucleus, nucleoplasm (UniProt).
No product in this corpus aims at WDR12 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
Broadly expressed or essential: HPA lists WDR12 among essential proteins and finds the RNA at low tissue specificity; a medicine acting on the wild-type protein would expose normal tissue too. HPA WDR12: RNA low tissue specificity; no normal tissue stained high; highest cancer staining colorectal cancer (6 of 12 high). Distribution: 1 cancer family in the corpus carries a prevalence row, label threshold or catalogue link for it (Brain and spinal cord tumours (all types)); Open Targets associates it with 0 specific cancer types at or above 0.5. (Rule 7 of scripts/fetch-target-specificity.ts.)
Sources: Human Protein Atlas WDR12 tissue; Open Targets ENSG00000138442 associations
First described 2000. Earliest sequence paper UniProt cites for the protein: Matsumoto, 2000, "Human homolog of Saccharomyces cervisiae YTM1". Source.
Sources: HGNC HGNC:14098 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q9GZL7 (protein name, function text, keywords and locations (REST API)); CIViC gene WDR12 (1 evidence items, 0 assertions, 1 variants; diseases: Glioblastoma (GraphQL API, CC0))
Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome. Location: Nucleus, nucleolus; Nucleus, nucleoplasm (UniProt). Locus 2q33.2 (HGNC).
RNA: low tissue specificity, detected in many normal tissues.
No normal tissue stained high.
Medium only: glioma, liver cancer, lung cancer, lymphoma.
HPA WDR12 tissue · HPA WDR12 pathology · HPA protein class: Essential proteins
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"WDR12" OR ABSTRACT:"WDR12" OR TITLE:"WD repeat domain 12" OR ABSTRACT:"WD repeat domain 12" OR TITLE:"Ribosome biogenesis protein WDR12" OR ABSTRACT:"Ribosome biogenesis protein WDR12" OR TITLE:"YTM1" OR ABSTRACT:"YTM1" OR TITLE:"FLJ10881" OR ABSTRACT:"FLJ10881") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about WDR12, not a curated reading list.