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VWF (von Willebrand factor) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Important in the maintenance of haemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet-surface receptor complex GPIb-IX-V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilising its heterodimeric structure and protecting it from premature clearance from plasma.
Open Targets scores its association with cancer at 0.66 (direct and indirect evidence; datatypes literature 0.98, affected pathway 0.97, animal model 0.53, genetic association 0.31).
In plain words · VWF (von Willebrand factor) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
VWF (von Willebrand factor) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Important in the maintenance of haemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet-surface receptor complex GPIb-IX-V.
No product in this corpus aims at VWF yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
First described 1985. Earliest sequence paper UniProt cites for the protein: Sadler J.E. et al, Proc. Natl. Acad. Sci. U.S.A, 1985, "Cloning and characterization of two cDNAs coding for human von Willebrand factor". Source.
Sources: HGNC HGNC:12726 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P04275 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000110799 (association with cancer (MONDO_0004992) 0.66; (GraphQL API, CC0))
Important in the maintenance of haemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet-surface receptor complex GPIb-IX-V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilising its heterodimeric structure and protecting it from premature clearance from plasma. Location: Secreted; Secreted, extracellular space, extracellular matrix (UniProt). Locus 12p13.31 (HGNC).
Query for this target: (TITLE:"VWF" OR ABSTRACT:"VWF" OR TITLE:"von Willebrand factor" OR ABSTRACT:"von Willebrand factor" OR TITLE:"F8VWF" OR ABSTRACT:"F8VWF") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about VWF, not a curated reading list.