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VTI1A (Vesicle transport through interaction with t-SNAREs homolog 1A) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
V-SNARE that mediates vesicle transport pathways through interactions with t-SNAREs on the target membrane. These interactions are proposed to mediate aspects of the specificity of vesicle trafficking and to promote fusion of the lipid bilayers. Involved in vesicular transport from the late endosomes to the trans-Golgi network.
Open Targets scores its association with cancer at 0.51 (direct and indirect evidence; datatypes literature 0.37, genetic association 0.60, somatic mutation 0.49).
In plain words · VTI1A (Vesicle transport through interaction with t-SNAREs homolog 1A) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
VTI1A (Vesicle transport through interaction with t-SNAREs homolog 1A) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
V-SNARE that mediates vesicle transport pathways through interactions with t-SNAREs on the target membrane.
No product in this corpus aims at VTI1A yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
First described 2004. Earliest sequence paper UniProt cites for the protein: Ota et al, Nat. Genet, 2004, "Complete sequencing and characterization of 21,243 full-length human cDNAs". Source.
Sources: HGNC HGNC:17792 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q96AJ9 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000151532 (association with cancer (MONDO_0004992) 0.51; (GraphQL API, CC0))
V-SNARE that mediates vesicle transport pathways through interactions with t-SNAREs on the target membrane. These interactions are proposed to mediate aspects of the specificity of vesicle trafficking and to promote fusion of the lipid bilayers. Involved in vesicular transport from the late endosomes to the trans-Golgi network. Along with VAMP7, involved in an non-conventional RAB1-dependent traffic route to the cell surface used by KCNIP1 and KCND2. May be involved in increased cytokine secretion associated with cellular senescence. Location: Cytoplasmic vesicle; Golgi apparatus membrane (UniProt). Locus 10q25.2 (HGNC).
Query for this target: (TITLE:"VTI1A" OR ABSTRACT:"VTI1A" OR TITLE:"vesicle transport through interaction with t-SNAREs 1A" OR ABSTRACT:"vesicle transport through interaction with t-SNAREs 1A" OR TITLE:"Vesicle transport through interaction with t-SNAREs homolog 1A" OR ABSTRACT:"Vesicle transport through interaction with t-SNAREs homolog 1A" OR TITLE:"MVti1" OR ABSTRACT:"MVti1" OR TITLE:"Vti1-rp2" OR ABSTRACT:"Vti1-rp2") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about VTI1A, not a curated reading list.