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VPS53 (Vacuolar protein sorting-associated protein 53 homolog) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Prostate cancer.
Acts as a component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex is required for the maintenance of the cycling of mannose 6-phosphate receptors between the TGN and endosomes, this cycling is necessary for proper lysosomal sorting of acid hydrolases such as CTSD. Acts as a component of the EARP complex that is involved in endocytic recycling.
Open Targets scores its association with cancer at 0.55 (direct and indirect evidence; datatypes literature 0.88, genetic association 0.69).
In plain words · VPS53 (Vacuolar protein sorting-associated protein 53 homolog) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Prostate cancer.
VPS53 (Vacuolar protein sorting-associated protein 53 homolog) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Prostate cancer.
Acts as a component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN).
No product in this corpus aims at VPS53 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
First described 2003. Earliest sequence paper UniProt cites for the protein: Zhao et al, Cancer Lett, 2003, "The minimum LOH region defined on chromosome 17p13.3 in human hepatocellular carcinoma with gene content analysis". Source.
Sources: HGNC HGNC:25608 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q5VIR6 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000141252 (association with cancer (MONDO_0004992) 0.55; per-cancer scores at or above 0.5: prostate cancer 0.53 (GraphQL API, CC0))
Acts as a component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex is required for the maintenance of the cycling of mannose 6-phosphate receptors between the TGN and endosomes, this cycling is necessary for proper lysosomal sorting of acid hydrolases such as CTSD. Acts as a component of the EARP complex that is involved in endocytic recycling. The EARP complex associates with Rab4-positive endosomes and promotes recycling of internalised transferrin receptor (TFRC) to the plasma membrane. Location: Golgi apparatus, trans-Golgi network membrane; Endosome membrane; Recycling endosome (UniProt). Locus 17p13.3 (HGNC).
Query for this target: (TITLE:"VPS53" OR ABSTRACT:"VPS53" OR TITLE:"VPS53 subunit of GARP complex" OR ABSTRACT:"VPS53 subunit of GARP complex" OR TITLE:"Vacuolar protein sorting-associated protein 53 homolog" OR ABSTRACT:"Vacuolar protein sorting-associated protein 53 homolog" OR TITLE:"FLJ10979" OR ABSTRACT:"FLJ10979" OR TITLE:"HCCS1" OR ABSTRACT:"HCCS1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about VPS53, not a curated reading list.