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VDR (Vitamin D3 receptor) is a protein that switches other genes on and off. The public catalogues list it as a drug target, and clinical evidence ties its variants to diagnosis, prognosis or drug response.
Nuclear receptor for calcitriol, the active form of vitamin D3 which mediates the action of this vitamin on cells. Enters the nucleus upon vitamin D3 binding where it forms heterodimers with the retinoid X receptor/RXR. The VDR-RXR heterodimers bind to specific response elements on DNA and activate the transcription of vitamin D3-responsive target genes.
Open Targets scores its association with cancer at 0.51 (direct and indirect evidence; datatypes literature 1.00, animal model 0.55, genetic association 0.46, clinical 0.67).
In plain words · VDR (Vitamin D3 receptor) is a protein that switches other genes on and off. The public catalogues list it as a drug target, and clinical evidence ties its variants to diagnosis, prognosis or drug response.
VDR (Vitamin D3 receptor) is a protein that switches other genes on and off. The public catalogues list it as a drug target, and clinical evidence ties its variants to diagnosis, prognosis or drug response.
Nuclear receptor for calcitriol, the active form of vitamin D3 which mediates the action of this vitamin on cells. Enters the nucleus upon vitamin D3 binding where it forms heterodimers with the retinoid X receptor/RXR.
No product in this corpus aims at VDR yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
Specificity not established: no corpus medicine is aimed at it and the catalogues give it only the role drug-target; HPA finds the RNA tissue enriched, which says where the protein sits but not whether the tumour differs from normal tissue. HPA VDR: RNA tissue enriched (parathyroid gland 222 nTPM); blood lineage group enriched (dendritic cells 5 nTPM, granulocytes 7 nTPM, monocytes 7 nTPM); no normal tissue stained high. Distribution: no corpus cancer carries a prevalence row, threshold or catalogue link for it; Open Targets associates it with 0 specific cancer types at or above 0.5. (No rule of scripts/fetch-target-specificity.ts fired.)
Sources: Human Protein Atlas VDR tissue; Open Targets ENSG00000111424 associations
First described 1988. Earliest sequence paper UniProt cites for the protein: Baker A.R. et al, Proc. Natl. Acad. Sci. U.S.A, 1988, "Cloning and expression of full-length cDNA encoding human vitamin D receptor". Source.
Sources: HGNC HGNC:12679 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P11473 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000111424 (association with cancer (MONDO_0004992) 0.51; (GraphQL API, CC0))
Nuclear receptor for calcitriol, the active form of vitamin D3 which mediates the action of this vitamin on cells. Enters the nucleus upon vitamin D3 binding where it forms heterodimers with the retinoid X receptor/RXR. The VDR-RXR heterodimers bind to specific response elements on DNA and activate the transcription of vitamin D3-responsive target genes. Plays a central role in calcium homeostasis. Also functions as a receptor for the secondary bile acid lithocholic acid (LCA) and its metabolites. Location: Nucleus; Cytoplasm (UniProt). Locus 12q13.11 (HGNC).
RNA: tissue enriched (parathyroid gland 222 nTPM), detected in many normal tissues. Blood: group enriched (dendritic cells 5 nTPM, granulocytes 7 nTPM, monocytes 7 nTPM).
No normal tissue stained high.
No cancer sample stained medium or high.
HPA VDR tissue · HPA VDR pathology · HPA protein class: FDA approved drug targets
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"VDR" OR ABSTRACT:"VDR" OR TITLE:"vitamin D receptor" OR ABSTRACT:"vitamin D receptor" OR TITLE:"Vitamin D3 receptor" OR ABSTRACT:"Vitamin D3 receptor" OR TITLE:"NR1I1" OR ABSTRACT:"NR1I1" OR TITLE:"PPP1R163" OR ABSTRACT:"PPP1R163") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about VDR, not a curated reading list.