Loading
VCL (Vinculin) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Actin filament (F-actin)-binding protein involved in cell-matrix adhesion and cell-cell adhesion. Regulates cell-surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion.
Open Targets scores its association with cancer at 0.62 (direct and indirect evidence; datatypes literature 0.96, affected pathway 0.97, genetic association 0.00).
In plain words · VCL (Vinculin) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
VCL (Vinculin) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Actin filament (F-actin)-binding protein involved in cell-matrix adhesion and cell-cell adhesion. Regulates cell-surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex.
No product in this corpus aims at VCL yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
First described 1990. Earliest sequence paper UniProt cites for the protein: Weller P.A. et al, Proc. Natl. Acad. Sci. U.S.A, 1990, "Complete sequence of human vinculin and assignment of the gene to chromosome 10". Source.
Sources: HGNC HGNC:12665 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P18206 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000035403 (association with cancer (MONDO_0004992) 0.62; (GraphQL API, CC0))
Actin filament (F-actin)-binding protein involved in cell-matrix adhesion and cell-cell adhesion. Regulates cell-surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion. Location: Cell membrane; Cell junction, adherens junction; Cell junction, focal adhesion; Cytoplasm, cytoskeleton (UniProt). Locus 10q22.2 (HGNC).
Query for this target: (TITLE:"VCL" OR ABSTRACT:"VCL" OR TITLE:"vinculin" OR ABSTRACT:"vinculin" OR TITLE:"Vinculin" OR ABSTRACT:"Vinculin") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about VCL, not a curated reading list.