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USP28 (Ubiquitin carboxyl-terminal hydrolase 28) is an enzyme. The public catalogues list it as a DNA repair gene, and the evidence so far is association rather than a proven role. Tied to Prostate cancer.
Deubiquitinase involved in DNA damage response checkpoint and MYC proto-oncogene stability. Involved in DNA damage induced apoptosis by specifically deubiquitinating proteins of the DNA damage pathway such as CLSPN. Also involved in G2 DNA damage checkpoint, by deubiquitinating CLSPN, and preventing its degradation by the anaphase promoting complex/cyclosome (APC/C).
Open Targets scores its association with cancer at 0.57 (direct and indirect evidence; datatypes literature 0.97, genetic association 0.69, somatic mutation 0.23).
In plain words · USP28 (Ubiquitin carboxyl-terminal hydrolase 28) is an enzyme. The public catalogues list it as a DNA repair gene, and the evidence so far is association rather than a proven role. Tied to Prostate cancer.
USP28 (Ubiquitin carboxyl-terminal hydrolase 28) is an enzyme. The public catalogues list it as a DNA repair gene, and the evidence so far is association rather than a proven role. Tied to Prostate cancer.
Deubiquitinase involved in DNA damage response checkpoint and MYC proto-oncogene stability. Involved in DNA damage induced apoptosis by specifically deubiquitinating proteins of the DNA damage pathway such as CLSPN.
No product in this corpus aims at USP28 yet. Inhibitors are shaped to fit the enzyme's active site so the reaction the cancer relies on stops.
First described 2000. Earliest sequence paper UniProt cites for the protein: Nagase et al, DNA Res, 2000, "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". Source.
Sources: HGNC HGNC:12625 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q96RU2 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000048028 (association with cancer (MONDO_0004992) 0.57; per-cancer scores at or above 0.5: prostate cancer 0.56 (GraphQL API, CC0))
Deubiquitinase involved in DNA damage response checkpoint and MYC proto-oncogene stability. Involved in DNA damage induced apoptosis by specifically deubiquitinating proteins of the DNA damage pathway such as CLSPN. Also involved in G2 DNA damage checkpoint, by deubiquitinating CLSPN, and preventing its degradation by the anaphase promoting complex/cyclosome (APC/C). In contrast, it does not deubiquitinate PLK1. Specifically deubiquitinates MYC in the nucleoplasm, leading to prevent MYC degradation by the proteasome: acts by specifically interacting with isoform 1 of FBXW7 (FBW7alpha) in the nucleoplasm and counteracting ubiquitination of MYC by the SCF(FBW7) complex. In contrast, it does not interact with isoform 4 of FBXW7 (FBW7gamma) in the nucleolus, allowing MYC degradation and explaining the selective MYC degradation in the nucleolus. Location: Nucleus, nucleoplasm (UniProt). Locus 11q23.2 (HGNC).
Query for this target: (TITLE:"USP28" OR ABSTRACT:"USP28" OR TITLE:"ubiquitin specific peptidase 28" OR ABSTRACT:"ubiquitin specific peptidase 28" OR TITLE:"Ubiquitin carboxyl-terminal hydrolase 28" OR ABSTRACT:"Ubiquitin carboxyl-terminal hydrolase 28" OR TITLE:"KIAA1515" OR ABSTRACT:"KIAA1515") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about USP28, not a curated reading list.