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UBTF (Nucleolar transcription factor 1) is a protein that switches other genes on and off. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Acute myeloid leukaemia.
Recognises the ribosomal RNA gene promoter and activates transcription mediated by RNA polymerase I (Pol I) through cooperative interactions with the transcription factor SL1/TIF-IB complex. It binds specifically to the upstream control element and can activate Pol I promoter escape.
CIViC holds 1 clinical evidence item and 2 assertions across 1 variant.
In plain words · UBTF (Nucleolar transcription factor 1) is a protein that switches other genes on and off. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Acute myeloid leukaemia.
UBTF (Nucleolar transcription factor 1) is a protein that switches other genes on and off. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Acute myeloid leukaemia.
Recognises the ribosomal RNA gene promoter and activates transcription mediated by RNA polymerase I (Pol I) through cooperative interactions with the transcription factor SL1/TIF-IB complex.
No product in this corpus aims at UBTF yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
Broadly expressed or essential: HPA lists UBTF among essential proteins and finds the RNA at low tissue specificity; a medicine acting on the wild-type protein would expose normal tissue too. HPA UBTF: RNA low tissue specificity; high antibody staining in 40 normal tissues; highest cancer staining colorectal cancer (10 of 12 high). Distribution: 1 cancer family in the corpus carries a prevalence row, label threshold or catalogue link for it (Leukaemia); Open Targets associates it with 0 specific cancer types at or above 0.5. (Rule 7 of scripts/fetch-target-specificity.ts.)
Sources: Human Protein Atlas UBTF tissue; Open Targets ENSG00000108312 associations
First described 1990. Earliest sequence paper UniProt cites for the protein: Jantzen H.M. et al, Nature, 1990, "Nucleolar transcription factor hUBF contains a DNA-binding motif with homology to HMG proteins". Source.
Sources: HGNC HGNC:12511 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P17480 (protein name, function text, keywords and locations (REST API)); CIViC gene UBTF (1 evidence items, 2 assertions, 1 variants; diseases: Acute Myeloid Leukaemia (GraphQL API, CC0))
Recognises the ribosomal RNA gene promoter and activates transcription mediated by RNA polymerase I (Pol I) through cooperative interactions with the transcription factor SL1/TIF-IB complex. It binds specifically to the upstream control element and can activate Pol I promoter escape. Location: Nucleus, nucleolus (UniProt). Locus 17q21.31 (HGNC).
RNA: low tissue specificity, detected in all normal tissues.
Medium: Endometrium, Liver, Prostate, Seminal vesicle.
HPA UBTF tissue · HPA UBTF pathology · HPA protein class: Essential proteins
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"UBTF" OR ABSTRACT:"UBTF" OR TITLE:"upstream binding transcription factor" OR ABSTRACT:"upstream binding transcription factor" OR TITLE:"Nucleolar transcription factor 1" OR ABSTRACT:"Nucleolar transcription factor 1" OR TITLE:"NOR-90" OR ABSTRACT:"NOR-90" OR TITLE:"UBF1" OR ABSTRACT:"UBF1" OR TITLE:"UBF2" OR ABSTRACT:"UBF2") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about UBTF, not a curated reading list.