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UBC (Polyubiquitin-C) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in proteotoxic stress response and cell cycle; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signalling processes leading to activation of the transcription factor NF-kappa-B.
Open Targets scores its association with cancer at 0.54 (direct and indirect evidence; datatypes literature 0.94, affected pathway 0.83, animal model 0.50, genetic association 0.00).
In plain words · UBC (Polyubiquitin-C) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
UBC (Polyubiquitin-C) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Exists either covalently attached to another protein, or free (unanchored).
No product in this corpus aims at UBC yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
First described 1975. Earliest sequence paper UniProt cites for the protein: Schlesinger D.H. et al, Nature, 1975, "Molecular conservation of 74 amino acid sequence of ubiquitin between cattle and man". Source.
Sources: HGNC HGNC:12468 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P0CG48 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000150991 (association with cancer (MONDO_0004992) 0.54; (GraphQL API, CC0))
Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in proteotoxic stress response and cell cycle; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signalling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signalling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signalling. Location: Cytoplasm; Nucleus; Mitochondrion outer membrane (UniProt). Locus 12q24.3 (HGNC).
Query for this target: (TITLE:"UBC" OR ABSTRACT:"UBC" OR TITLE:"ubiquitin C" OR ABSTRACT:"ubiquitin C" OR TITLE:"Polyubiquitin-C" OR ABSTRACT:"Polyubiquitin-C") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about UBC, not a curated reading list.