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TUBB8 (Tubulin beta-8 chain) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Breast cancer, Lung cancer, Non-Hodgkin lymphoma and 5 more.
Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilising cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
Open Targets scores its association with cancer at 0.61 (direct and indirect evidence; datatypes literature 0.07, genetic association 0.00, somatic mutation 0.00, clinical 1.00).
In plain words · TUBB8 (Tubulin beta-8 chain) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Breast cancer, Lung cancer, Non-Hodgkin lymphoma and 5 more.
TUBB8 (Tubulin beta-8 chain) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Breast cancer, Lung cancer, Non-Hodgkin lymphoma and 5 more.
Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers.
No product in this corpus aims at TUBB8 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
Specificity not established: no corpus medicine is aimed at it and the catalogues give it only the role drug-target; HPA finds the RNA tissue enhanced, which says where the protein sits but not whether the tumour differs from normal tissue. HPA TUBB8: RNA tissue enhanced (ovary 2 nTPM, testis 2 nTPM); no normal tissue stained high; highest cancer staining testis cancer (3 of 11 high). Distribution: 7 cancer families in the corpus carry a prevalence row, label threshold or catalogue link for it (Breast cancer (all types), Lung cancer (all types), Lymphoma, Prostate cancer, Cervical cancer, Multiple myeloma, Sarcomas (soft tissue, bone, GIST)); Open Targets associates it with 19 specific cancer types at or above 0.5 (non-small cell lung carcinoma, breast cancer, breast carcinoma, Hodgkins lymphoma, cervical cancer, plasma cell myeloma and more). (No rule of scripts/fetch-target-specificity.ts fired.)
Sources: Human Protein Atlas TUBB8 tissue; Open Targets ENSG00000261456 associations
First described 2002. Earliest sequence paper UniProt cites for the protein: van Geel et al, Am. J. Hum. Genet, 2002, "A cascade of complex subtelomeric duplications during the evolution of the hominoid and Old World monkey genomes". Source.
Sources: HGNC HGNC:20773 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q3ZCM7 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000261456 (association with cancer (MONDO_0004992) 0.61; per-cancer scores at or above 0.5: non-small cell lung carcinoma 0.61, gastric cancer 0.53, prostate cancer 0.59, ovarian cancer 0.56, cervical cancer 0.58, head and neck squamous cell carcinoma 0.53 (GraphQL API, CC0))
Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilising cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. TUBB8 has a key role in meiotic spindle assembly and oocyte maturation. Location: Cytoplasm, cytoskeleton; Cytoplasm, cytoskeleton, spindle (UniProt). Locus 10p15.3 (HGNC).
RNA: tissue enhanced (ovary 2 nTPM, testis 2 nTPM), detected in some normal tissues.
No normal tissue stained high.
RNA cancer enriched: Testicular Germ Cell Tumor 4 pTPM.
Medium only: breast cancer, cervical cancer, colorectal cancer, endometrial cancer.
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"TUBB8" OR ABSTRACT:"TUBB8" OR TITLE:"tubulin beta 8 class VIII" OR ABSTRACT:"tubulin beta 8 class VIII" OR TITLE:"Tubulin beta-8 chain" OR ABSTRACT:"Tubulin beta-8 chain" OR TITLE:"bA631M21.2" OR ABSTRACT:"bA631M21.2") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about TUBB8, not a curated reading list.