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TUBB4B (Tubulin beta-4B chain) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Lung cancer, Breast cancer, Non-Hodgkin lymphoma and 5 more.
Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilising cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
Open Targets scores its association with cancer at 0.65 (direct and indirect evidence; datatypes literature 0.54, affected pathway 0.25, genetic association 0.00, clinical 1.00).
In plain words · TUBB4B (Tubulin beta-4B chain) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Lung cancer, Breast cancer, Non-Hodgkin lymphoma and 5 more.
TUBB4B (Tubulin beta-4B chain) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Lung cancer, Breast cancer, Non-Hodgkin lymphoma and 5 more.
Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers.
No product in this corpus aims at TUBB4B yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
Broadly expressed or essential: HPA finds the RNA at low tissue specificity; a medicine acting on the wild-type protein would expose normal tissue too. HPA TUBB4B: RNA low tissue specificity; high antibody staining in 7 normal tissues; highest cancer staining glioma (5 of 11 high). Distribution: 7 cancer families in the corpus carry a prevalence row, label threshold or catalogue link for it (Lung cancer (all types), Breast cancer (all types), Lymphoma, Prostate cancer, Cervical cancer, Multiple myeloma, Sarcomas (soft tissue, bone, GIST)); Open Targets associates it with 19 specific cancer types at or above 0.5 (non-small cell lung carcinoma, breast cancer, breast carcinoma, Hodgkins lymphoma, plasma cell myeloma, cervical cancer and more). (Rule 7 of scripts/fetch-target-specificity.ts.)
Sources: Human Protein Atlas TUBB4B tissue; Open Targets ENSG00000188229 associations
First described 1985. Earliest sequence paper UniProt cites for the protein: Lewis S.A. et al, J. Mol. Biol, 1985, "Three expressed sequences within the human beta-tubulin multigene family each define a distinct isotype". Source.
Sources: HGNC HGNC:20771 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P68371 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000188229 (association with cancer (MONDO_0004992) 0.65; per-cancer scores at or above 0.5: non-small cell lung carcinoma 0.62, gastric cancer 0.57, prostate cancer 0.59, ovarian cancer 0.57, cervical cancer 0.58, head and neck squamous cell carcinoma 0.53 (GraphQL API, CC0))
Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilising cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. Location: Cytoplasm, cytoskeleton; Cytoplasm, cytoskeleton, flagellum axoneme (UniProt). Locus 9q34.3 (HGNC).
RNA: low tissue specificity, detected in all normal tissues.
Medium: Adrenal gland, Appendix, Bone marrow, Breast, Cerebral cortex, Colon, Endometrium, Esophagus.
Medium only: liver cancer, lung cancer, melanoma, skin cancer.
HPA TUBB4B tissue · HPA TUBB4B pathology · HPA protein class: FDA approved drug targets
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"TUBB4B" OR ABSTRACT:"TUBB4B" OR TITLE:"tubulin beta 4B class IVb" OR ABSTRACT:"tubulin beta 4B class IVb" OR TITLE:"Tubulin beta-4B chain" OR ABSTRACT:"Tubulin beta-4B chain" OR TITLE:"Beta2" OR ABSTRACT:"Beta2" OR TITLE:"TUBB2C" OR ABSTRACT:"TUBB2C") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about TUBB4B, not a curated reading list.