Loading
TUBB4A (Tubulin beta-4A chain) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Prostate cancer, Breast cancer, Lung cancer and 5 more.
Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilising cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
Open Targets scores its association with cancer at 0.64 (direct and indirect evidence; datatypes literature 0.87, animal model 0.53, genetic association 0.00, clinical 1.00).
In plain words · TUBB4A (Tubulin beta-4A chain) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Prostate cancer, Breast cancer, Lung cancer and 5 more.
TUBB4A (Tubulin beta-4A chain) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Prostate cancer, Breast cancer, Lung cancer and 5 more.
Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers.
No product in this corpus aims at TUBB4A yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
Specificity not established: no corpus medicine is aimed at it and the catalogues give it only the role drug-target; HPA finds the RNA tissue enriched, which says where the protein sits but not whether the tumour differs from normal tissue. HPA TUBB4A: RNA tissue enriched (brain 1,156 nTPM); blood lineage group enriched (B-cells 4 nTPM, T-cells 5 nTPM); high antibody staining in 1 normal tissue. Distribution: 7 cancer families in the corpus carry a prevalence row, label threshold or catalogue link for it (Prostate cancer, Breast cancer (all types), Lung cancer (all types), Lymphoma, Sarcomas (soft tissue, bone, GIST), Cervical cancer, Multiple myeloma); Open Targets associates it with 19 specific cancer types at or above 0.5 (non-small cell lung carcinoma, breast cancer, breast carcinoma, prostate cancer, Hodgkins lymphoma, diffuse large B-cell lymphoma and more). (No rule of scripts/fetch-target-specificity.ts fired.)
Sources: Human Protein Atlas TUBB4A tissue; Open Targets ENSG00000104833 associations
First described 1984. Earliest sequence paper UniProt cites for the protein: Lee M.G.-S. et al, Nucleic Acids Res, 1984, "Sequence of an expressed human beta-tubulin gene containing ten Alu family members". Source.
Sources: HGNC HGNC:20774 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P04350 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000104833 (association with cancer (MONDO_0004992) 0.64; per-cancer scores at or above 0.5: non-small cell lung carcinoma 0.61, gastric cancer 0.53, prostate cancer 0.62, ovarian cancer 0.56, cervical cancer 0.58, head and neck squamous cell carcinoma 0.54 (GraphQL API, CC0))
Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilising cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. Location: Cytoplasm, cytoskeleton (UniProt). Locus 19p13.3 (HGNC).
RNA: tissue enriched (brain 1,156 nTPM), detected in many normal tissues. Blood: group enriched (B-cells 4 nTPM, T-cells 5 nTPM).
Medium: Adrenal gland, Cerebral cortex.
RNA group enriched: Glioblastoma Multiforme 145 pTPM, Skin Cutaneous Melanoma 232 pTPM, Testicular Germ Cell Tumor 151 pTPM.
No cancer stained high; medium in carcinoid, endometrial cancer, glioma, ovarian cancer.
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"TUBB4A" OR ABSTRACT:"TUBB4A" OR TITLE:"tubulin beta 4A class IVa" OR ABSTRACT:"tubulin beta 4A class IVa" OR TITLE:"Tubulin beta-4A chain" OR ABSTRACT:"Tubulin beta-4A chain" OR TITLE:"beta-5" OR ABSTRACT:"beta-5" OR TITLE:"TUBB4" OR ABSTRACT:"TUBB4" OR TITLE:"DYT4" OR ABSTRACT:"DYT4") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about TUBB4A, not a curated reading list.