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TUBB2B (Tubulin beta-2B chain) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Breast cancer, Lung cancer, Sarcomas and 5 more.
Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilising cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
Open Targets scores its association with cancer at 0.64 (direct and indirect evidence; datatypes literature 0.84, animal model 0.68, genetic association 0.00, clinical 1.00).
In plain words · TUBB2B (Tubulin beta-2B chain) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Breast cancer, Lung cancer, Sarcomas and 5 more.
TUBB2B (Tubulin beta-2B chain) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Breast cancer, Lung cancer, Sarcomas and 5 more.
Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers.
No product in this corpus aims at TUBB2B yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
Specificity not established: no corpus medicine is aimed at it and the catalogues give it only the role drug-target; HPA finds the RNA tissue enriched, which says where the protein sits but not whether the tumour differs from normal tissue. HPA TUBB2B: RNA tissue enriched (brain 596 nTPM); high antibody staining in 1 normal tissue. Distribution: 7 cancer families in the corpus carry a prevalence row, label threshold or catalogue link for it (Breast cancer (all types), Lung cancer (all types), Sarcomas (soft tissue, bone, GIST), Prostate cancer, Lymphoma, Cervical cancer, Multiple myeloma); Open Targets associates it with 19 specific cancer types at or above 0.5 (breast cancer, breast carcinoma, non-small cell lung carcinoma, Hodgkins lymphoma, cervical cancer, plasma cell myeloma and more). (No rule of scripts/fetch-target-specificity.ts fired.)
Sources: Human Protein Atlas TUBB2B tissue; Open Targets ENSG00000137285 associations
First described 2003. Earliest sequence paper UniProt cites for the protein: Mungall A.J. et al, Nature, 2003, "The DNA sequence and analysis of human chromosome 6". Source.
Sources: HGNC HGNC:30829 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q9BVA1 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000137285 (association with cancer (MONDO_0004992) 0.64; per-cancer scores at or above 0.5: non-small cell lung carcinoma 0.61, gastric cancer 0.54, prostate cancer 0.60, ovarian cancer 0.56, cervical cancer 0.58, head and neck squamous cell carcinoma 0.53 (GraphQL API, CC0))
Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilising cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. Plays a critical role in proper axon guidance in both central and peripheral axon tracts. Implicated in neuronal migration. Location: Cytoplasm, cytoskeleton (UniProt). Locus 6p25.2 (HGNC).
RNA: tissue enriched (brain 596 nTPM), detected in many normal tissues.
Medium: Cerebral cortex.
RNA cancer enriched: Glioblastoma Multiforme 842 pTPM.
No cancer stained high; medium in carcinoid, endometrial cancer, glioma, ovarian cancer.
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"TUBB2B" OR ABSTRACT:"TUBB2B" OR TITLE:"tubulin beta 2B class IIb" OR ABSTRACT:"tubulin beta 2B class IIb" OR TITLE:"Tubulin beta-2B chain" OR ABSTRACT:"Tubulin beta-2B chain" OR TITLE:"MGC8685" OR ABSTRACT:"MGC8685" OR TITLE:"DKFZp566F223" OR ABSTRACT:"DKFZp566F223" OR TITLE:"bA506K6.1" OR ABSTRACT:"bA506K6.1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about TUBB2B, not a curated reading list.