Loading
TUBB2A (Tubulin beta-2A chain) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Breast cancer, Lung cancer, Non-Hodgkin lymphoma and 5 more.
Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilising cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
Open Targets scores its association with cancer at 0.63 (direct and indirect evidence; datatypes literature 0.84, genetic association 0.00, clinical 1.00).
In plain words · TUBB2A (Tubulin beta-2A chain) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Breast cancer, Lung cancer, Non-Hodgkin lymphoma and 5 more.
TUBB2A (Tubulin beta-2A chain) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Breast cancer, Lung cancer, Non-Hodgkin lymphoma and 5 more.
Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers.
No product in this corpus aims at TUBB2A yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
Specificity not established: no corpus medicine is aimed at it and the catalogues give it only the role drug-target; HPA finds the RNA tissue enriched, which says where the protein sits but not whether the tumour differs from normal tissue. HPA TUBB2A: RNA tissue enriched (brain 542 nTPM); blood lineage group enriched (B-cells 3 nTPM, monocytes 2 nTPM, T-cells 3 nTPM); high antibody staining in 3 normal tissues. Distribution: 7 cancer families in the corpus carry a prevalence row, label threshold or catalogue link for it (Breast cancer (all types), Lung cancer (all types), Lymphoma, Prostate cancer, Cervical cancer, Multiple myeloma, Sarcomas (soft tissue, bone, GIST)); Open Targets associates it with 19 specific cancer types at or above 0.5 (breast cancer, breast carcinoma, non-small cell lung carcinoma, Hodgkins lymphoma, cervical cancer, plasma cell myeloma and more). (No rule of scripts/fetch-target-specificity.ts fired.)
Sources: Human Protein Atlas TUBB2A tissue; Open Targets ENSG00000137267 associations
First described 1994. Earliest sequence paper UniProt cites for the protein: Leffers et al, 1994, "Cloning and vaccinia virus expression of a cDNA containing the complete coding sequence of human beta tubulin mRNA". Source.
Sources: HGNC HGNC:12412 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q13885 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000137267 (association with cancer (MONDO_0004992) 0.63; per-cancer scores at or above 0.5: non-small cell lung carcinoma 0.61, gastric cancer 0.55, prostate cancer 0.59, ovarian cancer 0.56, cervical cancer 0.58, head and neck squamous cell carcinoma 0.53 (GraphQL API, CC0))
Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilising cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. Location: Cytoplasm, cytoskeleton (UniProt). Locus 6p25.2 (HGNC).
RNA: tissue enriched (brain 542 nTPM), detected in all normal tissues. Blood: group enriched (B-cells 3 nTPM, monocytes 2 nTPM, T-cells 3 nTPM).
Medium: Cerebral cortex.
RNA cancer enhanced: Glioblastoma Multiforme 304 pTPM.
No cancer stained high; medium in carcinoid, endometrial cancer, glioma, ovarian cancer.
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"TUBB2A" OR ABSTRACT:"TUBB2A" OR TITLE:"tubulin beta 2A class IIa" OR ABSTRACT:"tubulin beta 2A class IIa" OR TITLE:"Tubulin beta-2A chain" OR ABSTRACT:"Tubulin beta-2A chain" OR TITLE:"dJ40E16.7" OR ABSTRACT:"dJ40E16.7" OR TITLE:"TUBB2" OR ABSTRACT:"TUBB2") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about TUBB2A, not a curated reading list.