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TUBB1 (Tubulin beta-1 chain) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Breast cancer, Lung cancer, Non-Hodgkin lymphoma and 5 more.
Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilising cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
Open Targets scores its association with cancer at 0.62 (direct and indirect evidence; datatypes literature 0.20, animal model 0.43, genetic association 0.00, clinical 1.00).
In plain words · TUBB1 (Tubulin beta-1 chain) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Breast cancer, Lung cancer, Non-Hodgkin lymphoma and 5 more.
TUBB1 (Tubulin beta-1 chain) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Breast cancer, Lung cancer, Non-Hodgkin lymphoma and 5 more.
Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers.
No product in this corpus aims at TUBB1 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
Specificity not established: no corpus medicine is aimed at it and the catalogues give it only the role drug-target; HPA finds the RNA tissue enhanced, which says where the protein sits but not whether the tumour differs from normal tissue. HPA TUBB1: RNA tissue enhanced (bone marrow 8 nTPM, lymphoid tissue 4 nTPM); blood lineage lineage enriched (granulocytes 63 nTPM); high antibody staining in 1 normal tissue; highest cancer staining testis cancer (3 of 11 high). Distribution: 7 cancer families in the corpus carry a prevalence row, label threshold or catalogue link for it (Breast cancer (all types), Lung cancer (all types), Lymphoma, Prostate cancer, Multiple myeloma, Cervical cancer, Sarcomas (soft tissue, bone, GIST)); Open Targets associates it with 19 specific cancer types at or above 0.5 (breast cancer, non-small cell lung carcinoma, breast carcinoma, Hodgkins lymphoma, plasma cell myeloma, cervical cancer and more). (No rule of scripts/fetch-target-specificity.ts fired.)
Sources: Human Protein Atlas TUBB1 tissue; Open Targets ENSG00000101162 associations
First described 2000. Earliest sequence paper UniProt cites for the protein: Gross et al, 2000, "Mapping and characterization of the human TUBB1 gene". Source.
Sources: HGNC HGNC:16257 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q9H4B7 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000101162 (association with cancer (MONDO_0004992) 0.62; per-cancer scores at or above 0.5: non-small cell lung carcinoma 0.61, gastric cancer 0.53, prostate cancer 0.59, ovarian cancer 0.56, cervical cancer 0.58, head and neck squamous cell carcinoma 0.53 (GraphQL API, CC0))
Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilising cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. Location: Cytoplasm, cytoskeleton (UniProt). Locus 20q13.32 (HGNC).
RNA: tissue enhanced (bone marrow 8 nTPM, lymphoid tissue 4 nTPM), detected in some normal tissues. Blood: lineage enriched (granulocytes 63 nTPM).
Medium: Adrenal gland, Appendix, Bone marrow, Breast, Bronchus, Cerebral cortex, Colon, Endometrium.
Medium only: breast cancer, cervical cancer, colorectal cancer, endometrial cancer.
HPA TUBB1 tissue · HPA TUBB1 pathology · HPA protein class: FDA approved drug targets
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"TUBB1" OR ABSTRACT:"TUBB1" OR TITLE:"tubulin beta 1 class VI" OR ABSTRACT:"tubulin beta 1 class VI" OR TITLE:"Tubulin beta-1 chain" OR ABSTRACT:"Tubulin beta-1 chain" OR TITLE:"dJ543J19.4" OR ABSTRACT:"dJ543J19.4") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about TUBB1, not a curated reading list.