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TUBA4A (Tubulin alpha-4A chain) is an enzyme. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Breast cancer, Lung cancer, Non-Hodgkin lymphoma and 5 more.
Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilising cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
Open Targets scores its association with cancer at 0.63 (direct and indirect evidence; datatypes literature 0.40, animal model 0.58, genetic association 0.00, clinical 1.00).
In plain words · TUBA4A (Tubulin alpha-4A chain) is an enzyme. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Breast cancer, Lung cancer, Non-Hodgkin lymphoma and 5 more.
TUBA4A (Tubulin alpha-4A chain) is an enzyme. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Breast cancer, Lung cancer, Non-Hodgkin lymphoma and 5 more.
Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers.
No product in this corpus aims at TUBA4A yet. Inhibitors are shaped to fit the enzyme's active site so the reaction the cancer relies on stops.
Specificity not established: no corpus medicine is aimed at it and the catalogues give it only the role drug-target; HPA finds the RNA tissue enhanced, which says where the protein sits but not whether the tumour differs from normal tissue. HPA TUBA4A: RNA tissue enhanced (skeletal muscle 346 nTPM, tongue 249 nTPM); high antibody staining in 35 normal tissues; highest cancer staining carcinoid (2 of 4 high). Distribution: 7 cancer families in the corpus carry a prevalence row, label threshold or catalogue link for it (Breast cancer (all types), Lung cancer (all types), Lymphoma, Prostate cancer, Sarcomas (soft tissue, bone, GIST), Cervical cancer, Multiple myeloma); Open Targets associates it with 19 specific cancer types at or above 0.5 (breast cancer, non-small cell lung carcinoma, breast carcinoma, Hodgkins lymphoma, cervical cancer, plasma cell myeloma and more). (No rule of scripts/fetch-target-specificity.ts fired.)
Sources: Human Protein Atlas TUBA4A tissue; Open Targets ENSG00000127824 associations
First described 1987. Earliest sequence paper UniProt cites for the protein: Dobner P.R. et al, Nucleic Acids Res, 1987, "Alternative 5' exons either provide or deny an initiator methionine codon to the same alpha-tubulin coding region". Source.
Sources: HGNC HGNC:12407 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P68366 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000127824 (association with cancer (MONDO_0004992) 0.63; per-cancer scores at or above 0.5: non-small cell lung carcinoma 0.61, gastric cancer 0.53, prostate cancer 0.59, ovarian cancer 0.56, cervical cancer 0.59, head and neck squamous cell carcinoma 0.53 (GraphQL API, CC0))
Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilising cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. Location: Cytoplasm, cytoskeleton (UniProt). Locus 2q35 (HGNC).
RNA: tissue enhanced (skeletal muscle 346 nTPM, tongue 249 nTPM), detected in all normal tissues.
Medium: Adipose tissue, Cerebellum, Kidney, Liver, Parathyroid gland, Smooth muscle, Spleen, Vagina.
Medium only: breast cancer, cervical cancer, colorectal cancer, head and neck cancer.
HPA TUBA4A tissue · HPA TUBA4A pathology · HPA protein class: FDA approved drug targets
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"TUBA4A" OR ABSTRACT:"TUBA4A" OR TITLE:"tubulin alpha 4a" OR ABSTRACT:"tubulin alpha 4a" OR TITLE:"Tubulin alpha-4A chain" OR ABSTRACT:"Tubulin alpha-4A chain" OR TITLE:"FLJ30169" OR ABSTRACT:"FLJ30169" OR TITLE:"H2-ALPHA" OR ABSTRACT:"H2-ALPHA" OR TITLE:"TUBA1" OR ABSTRACT:"TUBA1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about TUBA4A, not a curated reading list.