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TUBA1C (Tubulin alpha-1C chain) is an enzyme. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Prostate cancer, Breast cancer, Lung cancer and 5 more.
Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilising cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
Open Targets scores its association with cancer at 0.70 (direct and indirect evidence; datatypes literature 0.96, genetic association 0.43, clinical 1.00).
In plain words · TUBA1C (Tubulin alpha-1C chain) is an enzyme. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Prostate cancer, Breast cancer, Lung cancer and 5 more.
TUBA1C (Tubulin alpha-1C chain) is an enzyme. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Prostate cancer, Breast cancer, Lung cancer and 5 more.
Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers.
No product in this corpus aims at TUBA1C yet. Inhibitors are shaped to fit the enzyme's active site so the reaction the cancer relies on stops.
Broadly expressed or essential: HPA lists TUBA1C among essential proteins; a medicine acting on the wild-type protein would expose normal tissue too. HPA TUBA1C: RNA tissue enhanced (esophagus 436 nTPM); high antibody staining in 35 normal tissues; highest cancer staining head and neck cancer (4 of 4 high). Distribution: 7 cancer families in the corpus carry a prevalence row, label threshold or catalogue link for it (Prostate cancer, Breast cancer (all types), Lung cancer (all types), Lymphoma, Cervical cancer, Sarcomas (soft tissue, bone, GIST), Multiple myeloma); Open Targets associates it with 19 specific cancer types at or above 0.5 (prostate cancer, breast cancer, breast carcinoma, non-small cell lung carcinoma, Hodgkins lymphoma, cervical cancer and more). (Rule 7 of scripts/fetch-target-specificity.ts.)
Sources: Human Protein Atlas TUBA1C tissue; Open Targets ENSG00000167553 associations
First described 2004. Earliest sequence paper UniProt cites for the protein: Genome Res, 2004, "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Source.
Sources: HGNC HGNC:20768 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q9BQE3 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000167553 (association with cancer (MONDO_0004992) 0.70; per-cancer scores at or above 0.5: non-small cell lung carcinoma 0.61, gastric cancer 0.55, prostate cancer 0.67, ovarian cancer 0.56, cervical cancer 0.59, head and neck squamous cell carcinoma 0.53 (GraphQL API, CC0))
Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilising cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. Location: Cytoplasm, cytoskeleton (UniProt). Locus 12q13.12 (HGNC).
RNA: tissue enhanced (esophagus 436 nTPM), detected in all normal tissues.
Medium: Adipose tissue, Cerebellum, Kidney, Liver, Parathyroid gland, Smooth muscle, Spleen, Vagina.
Medium only: pancreatic cancer.
HPA TUBA1C tissue · HPA TUBA1C pathology · HPA protein class: Essential proteins
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"TUBA1C" OR ABSTRACT:"TUBA1C" OR TITLE:"tubulin alpha 1c" OR ABSTRACT:"tubulin alpha 1c" OR TITLE:"Tubulin alpha-1C chain" OR ABSTRACT:"Tubulin alpha-1C chain" OR TITLE:"MGC14580" OR ABSTRACT:"MGC14580" OR TITLE:"MGC10851" OR ABSTRACT:"MGC10851" OR TITLE:"bcm948" OR ABSTRACT:"bcm948") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about TUBA1C, not a curated reading list.