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TUBA1B (Tubulin alpha-1B chain) is an enzyme. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Breast cancer, Lung cancer, Prostate cancer and 5 more.
Tubulin is the major constituent of microtubules, protein filaments consisting of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilising cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
Open Targets scores its association with cancer at 0.64 (direct and indirect evidence; datatypes literature 0.94, genetic association 0.00, clinical 1.00).
In plain words · TUBA1B (Tubulin alpha-1B chain) is an enzyme. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Breast cancer, Lung cancer, Prostate cancer and 5 more.
TUBA1B (Tubulin alpha-1B chain) is an enzyme. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Breast cancer, Lung cancer, Prostate cancer and 5 more.
Tubulin is the major constituent of microtubules, protein filaments consisting of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilising cap forms.
No product in this corpus aims at TUBA1B yet. Inhibitors are shaped to fit the enzyme's active site so the reaction the cancer relies on stops.
Broadly expressed or essential: HPA lists TUBA1B among essential proteins and finds the RNA at low tissue specificity; a medicine acting on the wild-type protein would expose normal tissue too. HPA TUBA1B: RNA low tissue specificity; high antibody staining in 35 normal tissues; highest cancer staining head and neck cancer (4 of 4 high). Distribution: 7 cancer families in the corpus carry a prevalence row, label threshold or catalogue link for it (Breast cancer (all types), Lung cancer (all types), Prostate cancer, Lymphoma, Multiple myeloma, Cervical cancer, Sarcomas (soft tissue, bone, GIST)); Open Targets associates it with 19 specific cancer types at or above 0.5 (breast cancer, breast carcinoma, non-small cell lung carcinoma, plasma cell myeloma, Hodgkins lymphoma, cervical cancer and more). (Rule 7 of scripts/fetch-target-specificity.ts.)
Sources: Human Protein Atlas TUBA1B tissue; Open Targets ENSG00000123416 associations
First described 1983. Earliest sequence paper UniProt cites for the protein: Cowan N.J. et al, Mol. Cell. Biol, 1983, "Expression of human alpha-tubulin genes: interspecies conservation of 3' untranslated regions". Source.
Sources: HGNC HGNC:18809 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P68363 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000123416 (association with cancer (MONDO_0004992) 0.64; per-cancer scores at or above 0.5: non-small cell lung carcinoma 0.61, gastric cancer 0.54, prostate cancer 0.60, ovarian cancer 0.57, cervical cancer 0.59, head and neck squamous cell carcinoma 0.53 (GraphQL API, CC0))
Tubulin is the major constituent of microtubules, protein filaments consisting of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilising cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. Location: Cytoplasm, cytoskeleton (UniProt). Locus 12q13.12 (HGNC).
RNA: low tissue specificity, detected in all normal tissues.
Medium: Adipose tissue, Cerebellum, Kidney, Liver, Parathyroid gland, Smooth muscle, Spleen, Vagina.
Medium only: pancreatic cancer.
HPA TUBA1B tissue · HPA TUBA1B pathology · HPA protein class: Essential proteins
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"TUBA1B" OR ABSTRACT:"TUBA1B" OR TITLE:"tubulin alpha 1b" OR ABSTRACT:"tubulin alpha 1b" OR TITLE:"Tubulin alpha-1B chain" OR ABSTRACT:"Tubulin alpha-1B chain" OR TITLE:"K-ALPHA-1" OR ABSTRACT:"K-ALPHA-1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about TUBA1B, not a curated reading list.